With just seven rounds left in the RaboDirect PRO12, the race is on for the top four finishing places and qualification for the play-off semi-finals.
And although the Scarlets face a tough ask against the Irish province, they are able to call on Aaron Shingler, Josh Turnbull and Rob McCusker who all start.
Head Coach Simon Easterby said: "We have to go back to October 2007 to find the last time we won at the RDS so we know we have plenty to do out there.
"Leinster have a very proud home record and we know from our encounters in Europe what intensity they can bring.
"We got a good win against them at the beginning of the season and that gives us heart. However, we're also well aware that we caught them a bit cold that day and you won't see that in a Leinster team too often."
Leinster have won their last six matches in all competitions and remain the only side with a 100% home record in the RaboDirect PRO12 this season. Easterby though, says his side are in good heart.
"We are pleased with the form we have coming into this game, it will be tough but the boys have responded well and with some continuity in selection, we are building," he added.
"Winning against Munster last weekend showed there were less errors in our game, we're not feeding the opposition and starting to reward ourselves more with good territory and field possession.
"We have put pressure on sides by taking our points from goal kicking and drop goals and rewarding our forwards for their efforts by keeping the scoreboard ticking over."