Both sides still have an outside chance to claim the Championship crown and will be desperate to triumph at Murrayfield.
And the fly-half reckons Wales will bring a different challenge to anything the Scots have faced so far in the tournament.
"The Welsh are really passionate, like the other Celtic nations, but they have got a bit more of a blitz defence and we will need to combat that," said Jackson.
"They have got some pretty big backs that are going to be running down some channels, the likes of George North and Jamie Roberts and Alex Cuthbert are all very dangerous.
"They will come with a different style to Ireland and we will need to combat that with some good defence."
Like Wales, Scotland crashed to an autumn whitewash but have been rejuvenated in the Six Nations.
They recorded back-to-back Championship triumphs for the first time in 12 years with the 12-8 victory over Ireland. The win was built upon rock solid defence and the deadly boot of Greig Laidlaw.
And Jackson reckons a return to basics has been crucial to Scotland's resurgence.
"It's hard to specify an exact thing that has changed," said Jackson.
"It's quite crazy to think it has been that long since we won back-to-back games in the Six Nations.
"It shows how frustrating a time it probably has been for Scotland.
"We are doing a lot of repetitions of our basics - the rucking, the tackle area and all these things that are the backbone of a good solid team.
"Anything on top of that is a bonus, and that will come."