The Dragons also make a number of other changes with Hugh Gustafson, Adam Jones and Owen Evans all starting in the front five.
A fresh back line sees Steffan Jones come in at fly half after impressing for Principality Premiership side Cross Keys over the last month. He is joined by Will Harries and Mike Poole who also take on the French side.
Darren Edwards' side are level on points with Bayonne going into tonight's game and know a win is vital if they are to keep up the pressure on Wasps at the top of the table.
Wales scrum half Mike Phillips starts on the bench for the French side.