Dimitri Yachvili gets a recall at scrum-half replacing the disappointing Julien Dupuy, while Florian Fritz is in at centre and Alexis Palisson comes back in on the wing.
Wesley Fofana, who has scored tries in each of France's four games so far in the tournament, switches to the wing to make way for Fritz.
France have no hope of winning the Six Nations title after two wins, one draw and one defeat, while their opponents will be aiming to complete the Grand Slam.
France Clement Poitrenaud (Toulouse); Wesley Fofana (Clermont), Aurelien Rougerie (Clermont), Florian Fritz (Toulouse), Alexis Palisson (Toulon); Lionel Beauxis (Toulouse), Dimitri Yachvili (Biarritz); Imanol Harinordoquy (Biarritz), Julien Bonnaire (Clermont), Thierry Dusautoir (Toulouse, capt); Yoann Maestri (Toulouse), Pascal Papé (Stade Français); David Attoub (Stade Français), William Servat (Toulouse), Jean-Baptiste Poux (Toulouse)
Replacements: Dimitri Szarzewski (Stade Français), Vincent Debaty (Clermont), Julien Pierre (Clermont), Louis Picamoles (Toulouse), Morgan Parra (Clermont), Francois Trinh-Duc (Montpellier), Jean-Marcellin Buttin (Clermont)