Up front, Ethan Lewis starts at hooker, Joe Davies will make his Wales Under 20 debut at lock, partnering Scott Andrews, and in the back row, Ben Roach and Ollie Griffiths will flank James Benjamin at No 8.
Hayward said: "This is a must win game for us. We didn't perform as we know we can against France so it's all about putting that right this week.
"We feel we have selected our strongest available side for this match. This is Jack Dixon's third season of Under 20 international rugby and Ashley Evans has recently added to his Wales Under 20 experience with a stint with Wales Sevens. Angus and Tyler deserve an opportunity to show what they can do, as do forwards Joe Davies and Ollie Griffiths getting their first starts.
"As you would expect, England are a very strong team, they had a good win over Ireland in the last round. However, we are concentrating on our own game and on ensuring our own mind-set is right on Friday night if we are to come away from Newcastle with a positive result. We always knew we would learn most about our players from the France and England games in this tournament."
Wales team v England (Friday 7 March, 7.45pm, Kingston Park, Sky Sports):
Afon Bagshaw (RGC); Tyler Morgan (Dragons), Steffan Hughes (capt, Scarlets), Jack Dixon (Dragons), Ashley Evans (Ospreys); Angus O'Brien (Dragons), Tom Williams (Blues); Nicky Smith (Ospreys), Ethan Lewis (Blues), Nicky Thomas (Ospreys), Scott Andrews (Dragons), Joe Davies (Dragons), Ben Roach (Blues), Ollie Griffiths (Dragons), James Benjamin (Dragons)
Replacements: Elliot Dee (Dragons), Luke Garrett (Dragons), Benjamin Leung (Scarlets), Rob Dudley-Jones (Ospreys), Will Boyde (Carmarthen), Luc Jones (Dragons), Luke Price (Ospreys), Joshua Adams (Scarlets)
Tickets are available for the final Wales Under 20 home game of the season - against Scotland on Friday 14 March (7pm). They are on sale now at Colwyn Leisure Centre and Venue Cymru (online at www.venuecymru.co.uk / tel 01492 872000/ The Promenade, Llandudno) and wru.co.uk/tickets from £5 Under 16s and from £10 for adults.
Wales Under 20 v Italy - Friday 31 January - Eirias (won, 26-9)
Ireland Under 20 v Wales - Friday 7 February - Dubarry Park, Ahtlone (won, 16-0)
Wales Under 20 v France - Saturday 22 February - Eirias - (lost, 10-16)
England Under 20 v Wales - Friday 7 March - Kingston Park, Newcastle - 7.45pm
Wales Under 20 v Scotland - Friday 14 March - Eirias - 7pm