Back rowers Johnathan Edwards and Kieran Murphy will both move on from Parc y Scarlets at the end of the current campaign.
Murphy, who started last Friday's defeat to Treviso, has impressed in the Principality Premiership for Llandovery this season and should be in contention for this Friday's PRO12 play-off clash with Ulster.
Simon Easterby's Scarlets travel to Ravenhill knowing a dramatically improved performance is required if they are to trouble the Irish side.
But looking ahead to next season, they will be without both Edwards and Murphy who are seeking pastures new.
Easterby said: "I would like to thank both players personally for all they have given to the Scarlets and for their commitment and dedication to our region both on and off the field.
"Both these players are good rugby professionals, work hard and have been a real credit to our region and our rugby environment. They have been popular members of the Scarlets squad both with supporters and colleagues and we all wish them the very best in their future careers."
Openside flanker Edwards leaves the Scarlets after an impressive 119 appearances, 60 points and over eight seasons with the West Wales side.
Born and raised in Llantwit Fardre, popular Scarlet Edwards was educated at Ysgol Gyfun Rhydfelen and is a fluent Welsh speaker. He joined the Scarlets in 2004 after spending time with Pontypridd, Cardiff and the Blues Academy.
No. 8 Murphy, 25, was born in Aberdeen, Scotland but has pushed his career on after benefitting from playing Scarlets senior rugby for the past two seasons.
He joined the Scarlets in June 2011 and made his debut against Leicester Tigers in the LV Cup, scoring two tries.
"Kieran has worked very hard at his game and his conditioning and his attitude has always been very professional at Parc y Scarlets," Easterby added.
"He is an intelligent and mature player and having come to pro rugby late, has achieved a great deal in a short time.
"Jonny Edwards has been a big part of this region for a number of years and has been a loyal servant to the Scarlets.
"He has captained our region with pride and has been a mainstay of our back row and a senior figure in our team over a number of years, helping guide and develop younger players during blocks of international rugby when we have lost large numbers of our squad.
"We are very grateful to him for his service to the Scarlets and he leaves with our sincere gratitude and appreciation for all he has given to our region."