Rhys Priestland will have scans today as Wales and the Scarlets sweat on the fly-half's fitness.
The 25-year-old was stretchered off with an Achilles injury after 47 minutes of the Scarlets' home defeat to Exeter Chiefs.
Priestland slipped while taking the ball into contact and could face an extended period on the sidelines.
"Rhys has got an Achilles injury," said Scarlets head coach Simon Easterby.
"We won't know the extent of that until he has a scan. But it didn't look good."
The Scarlets' woes were compounded by further injuries suffered by Aaron Shingler and Samson Lee.
Shingler, a shining light in Wales' autumn campaign, came off with a groin problem while Lee injured his shoulder.
"Aaron Shingler suffered a groin injury and he's been carrying that for a couple of weeks," added Easterby.
"Hopefully he will come through but that didn't look great either."
The injured trio are just the latest worries for Rob Howley ahead of the 2013 RBS Six Nations.
Adam Jones, Aaron Jarvis, Craig Mitchell, Ian Evans, Alun Wyn Jones and Dan Lydiate all remain on the sidelines, as do George North, Leigh Halfpenny and Jamie Roberts.
But Roberts and Halfpenny are both set to be fit for the Championship with return dates pencilled in for mid-January.
"We've had a few opinions now from the specialists and it seems to be about six weeks will be there time where the nerve will have settled down and it'll be safe to go back to play," added the Cardiff Blues full-back
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Forwards coach Robyn McBryde says tomorrow's RBS 6 Nations clash against Italy gives Wales an opportunity to finish second in the tournament after having the wind knocked from their sails last week against England.
Wales head coach Warren Gatland tells WRU TV that his selection for the final clash of the RBS 6 Nations against Italy is an opportunity for some players to redeem themselves after Saturday's loss to England
Wales head coach Warren Gatland is expecting 'one heck of a game' when his side tackle England at Twickenham on Saturday in the RBS 6 Nations. He believes whoever wins the game, could go on to win the championship.
Wales head coach Warren Gatland sticks to an experienced side to face England at Twickenham on Saturday where he says his side are approaching the RBS 6 Nations clash as a 'final' - if they win against the red rose brigade on Saturday then they are in the driving seat for the Six Nations title.