Cardiff Blues have been dealt a blow after Jamie Roberts was sidelined for up to six weeks.
The Wales star suffered a hyperextension of his elbow in last weekend's agonising 14-12 defeat to Australia.
He saw a specialist yesterday and is expected to be out of action for up to six weeks.
The powerful centre heads an alarming injury list for the Blues, who are also without Leigh Halfpenny and Bradley Davies.
Halfpenny is recovering from a severe stinger and continues to be assesses and Davies is expected to return to training next week following severe concussion.
Michael Patterson, Dan Fish, Andi Kyriacou and Tom James are also recent additions to the treatment room and are likely to miss the back-to-back clashes with Montpellier.
Blues director of rugby Phil Davies admits the injuries are frustrating but he has urged his fringe players to step up and prove a point.
"Only a fortnight ago things were looking very positive for us, when we were welcoming back some key players," said Davies.
'However, we have been extremely unfortunate to pick up a raft of injuries in the last few weeks.
"It is frustrating that we cannot select from a full strength squad for these crucial matches, but on a positive note, it gives a chance for some of our other players to step up and show what they can do.
"Montpellier has a formidable reputation in the French league as a very physical team with an extremely strong set-piece.
"Their scrum is particularly strong this season, having won all 17 of their put-ins so far in both Heineken Cup games and their six lineout steals is a joint high this season.
"These are areas in which we will have to be at our best if we are to compete this Sunday."
British and Irish Lions head coach Warren Gatland will be heading back home to take on the All Blacks next year where for him, success for 2017 is all about going to New Zealand and winning a Test Series.
James Davies was one of three Welsh players announced in Team GB's men's sevens squad for Rio yesterday at a sweltering Trafalgar Square. WRU TV's Graeme Gillespie battles with a Japanese tour guide as 'Cubby' reveals who has made his teammate, Sam Cross, the player he is today.
Robin McBryde and son Billy are set to represent Wales on either side of the globe over the coming weeks with Robin travelling to New Zealand as Wales assistant coach and Billy competing at the World Rugby U20 Championship (Manchester, June 7-25). WRU TV caught up with the pair and captured a unique perspective into the factors that produce such a high-achieving rugby family.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Cardiff Blues hung on to win 23-21 in Italy and extend their unbeaten run in the Guinness PRO12 to four matches.
Having lost five and drawn one of their last 10 PRO12 visits to Italy the Blues travelled hoping to end their Italian curse.
The Welsh Rugby Union, together with Pro Rugby Wales, has secured significantly improved insurance cover for all registered players, coaches and referees at each of its member clubs and regions at reduced costs -working with Aon, one of the world's largest insurance brokers and risk advisors.
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