Cardiff Blues have been dealt a blow after Jamie Roberts was sidelined for up to six weeks.
The Wales star suffered a hyperextension of his elbow in last weekend's agonising 14-12 defeat to Australia.
He saw a specialist yesterday and is expected to be out of action for up to six weeks.
The powerful centre heads an alarming injury list for the Blues, who are also without Leigh Halfpenny and Bradley Davies.
Halfpenny is recovering from a severe stinger and continues to be assesses and Davies is expected to return to training next week following severe concussion.
Michael Patterson, Dan Fish, Andi Kyriacou and Tom James are also recent additions to the treatment room and are likely to miss the back-to-back clashes with Montpellier.
Blues director of rugby Phil Davies admits the injuries are frustrating but he has urged his fringe players to step up and prove a point.
"Only a fortnight ago things were looking very positive for us, when we were welcoming back some key players," said Davies.
'However, we have been extremely unfortunate to pick up a raft of injuries in the last few weeks.
"It is frustrating that we cannot select from a full strength squad for these crucial matches, but on a positive note, it gives a chance for some of our other players to step up and show what they can do.
"Montpellier has a formidable reputation in the French league as a very physical team with an extremely strong set-piece.
"Their scrum is particularly strong this season, having won all 17 of their put-ins so far in both Heineken Cup games and their six lineout steals is a joint high this season.
"These are areas in which we will have to be at our best if we are to compete this Sunday."
Defence coach Shaun Edwards believes Saturday's clash against England - the 'form team in world rugby' - poses a huge challenge for his side but he is confident, with Wales beginning to show the defensive qualities displayed in the last two World Cups,
At the official launch of this season's RBS 6 Nations at a noisy location in London this morning, Wales captain Alun Wyn Jones reveals he is personally proud to be in the Wales team and is already looking forward to the opening clash against Italy which is a 'tough ask'.
It was a double celebration for Wales and Ospreys scrum-half Rhys Webb when he called at the home of Welsh rugby to help commemorate the first anniversary of Principality Stadium and his return to fitness this weekend ahead of the RBS 6 Nations.
The Ospreys had their hearts in their mouths thinking the Dragons had stolen the WRU U18 Regional Championship from under their noses, but a TMO decision went in their favour for the Eyasses to be crowned champions at a wet Sardis Road.
The Ospreys may begin tonight's final of the WRU Regional U18 Championship against the Dragons as firm favourites, but the lure of a possible spot on Wales U18 training squad is a goal for all players competing in the double header at Sardis Road.
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