The Scarlets face the daunting task of hosting the PRO12 runners-up on the opening week, while Newport Gwent Dragons welcome new Italian side Zebre and Cardiff Blues travel to Connacht.
The Ospreys make their first appearance at the Liberty Stadium since winning the title against Ulster on the second-week of the season, as Tommy Bowe returns to his former region.
The first Welsh derby will take place on 14/15/16 September with the Blues travelling to Rodney Parade.
During the Festive season the Dragons host the Ospreys at Chirstmas, while the Blues will travel to Parc y Scarlets.
The New Year's derbies will feature Blues v Dragons and Ospreys v Scarlets at the Liberty Stadium.
Dates and kick-off times for all fixtures have yet to be confirmed.