Argentina captain Juan Martin Fernandez Lobbe has been ruled out of the Dove Men Series clash with Wales on November 16.
The 31-year-old flanker fractured his elbow during Toulon's Top14 defeat to Toulouse on Saturday and is set to be sidelined for up to three months.
"Against Toulouse on Saturday flanker Juan Martin Fernandez Lobbe suffered a fracture of the right elbow," read a Toulon statement.
"He will consult a Marseille professor for surgery. It is estimated he will be unavailable for two to three months."
Argentina also face England, Italy and Ireland during their European tour.
Meanwhile former Wales head coach Sir Graham Henry has left his role as technical advisor to Los Pumas.
The World Cup winning-coach has stepped down to focus on a similar role with Super Rugby side the Blues.
He is just the latest departure from the Pumas' coaching staff after Santiago Phelan quit his role in charge. Phelan had been at the helm for six years but will be replaced by Argentina B coach Daniel Hourcade.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Forwards coach Robyn McBryde says tomorrow's RBS 6 Nations clash against Italy gives Wales an opportunity to finish second in the tournament after having the wind knocked from their sails last week against England.
Wales head coach Warren Gatland tells WRU TV that his selection for the final clash of the RBS 6 Nations against Italy is an opportunity for some players to redeem themselves after Saturday's loss to England
Ebbw Vale clinch the Principality Premiership while Wales U20 hold a special training camp in Monmouth, in this week's Principality Welsh Rugby Union Podcast. We hear from Steelmen skipper Damien Hudd, as well as Wales U20 coach and captain, Jason Strange and Tom Phillips, WRU group chief executive Martyn Phillips, Wales wing Hallam Amos, WRU national performance manager Gethin Watts and Wales U20 consultant Dr Rich Neil of Cardiff Metropolitan University.
Mid way through their preparations for the forthcoming World Rugby U20 Championship (Manchester, June 7 - 25), Wales U20 head coach Jason Strange is taking his squad to Monmouth for a three day training camp next week.