Argentina captain Juan Martin Fernandez Lobbe has been ruled out of the Dove Men Series clash with Wales on November 16.
The 31-year-old flanker fractured his elbow during Toulon's Top14 defeat to Toulouse on Saturday and is set to be sidelined for up to three months.
"Against Toulouse on Saturday flanker Juan Martin Fernandez Lobbe suffered a fracture of the right elbow," read a Toulon statement.
"He will consult a Marseille professor for surgery. It is estimated he will be unavailable for two to three months."
Argentina also face England, Italy and Ireland during their European tour.
Meanwhile former Wales head coach Sir Graham Henry has left his role as technical advisor to Los Pumas.
The World Cup winning-coach has stepped down to focus on a similar role with Super Rugby side the Blues.
He is just the latest departure from the Pumas' coaching staff after Santiago Phelan quit his role in charge. Phelan had been at the helm for six years but will be replaced by Argentina B coach Daniel Hourcade.
Forwards coach Robyn McBryde says tomorrow's RBS 6 Nations clash against Italy gives Wales an opportunity to finish second in the tournament after having the wind knocked from their sails last week against England.
Wales head coach Warren Gatland tells WRU TV that his selection for the final clash of the RBS 6 Nations against Italy is an opportunity for some players to redeem themselves after Saturday's loss to England
Wales Women's head coach Rhys Edwards believes his side is back on track in terms of objectives and is confident his side can emulate last year's achievement by beating England for a second consecutive year on Saturday.
Wales head coach Warren Gatland is expecting 'one heck of a game' when his side tackle England at Twickenham on Saturday in the RBS 6 Nations. He believes whoever wins the game, could go on to win the championship.
The Welsh Rugby Union has announced a significant partnership extension with Welsh brewer and hospitality retailer Brains and the UK's leading lager and cider producer Heineken which will stretch through to the summer of 2018.
A bitterly disappointed Wales head coach Gareth Williams was left scratching his head at his team's abject performances in the Singapore Sevens which culminated in an 'awful' display against Russia in the Bowl final.
The pressure is off and the Welsh Women's team hope to end their Six Nations Championship on a high by recording a third win when they host Italy at the Talbot Athletic Ground, Aberavon on Sunday (2.00pm).