Talismanic Italy skipper Sergio Parisse will miss Saturday's showdown against Wales after being suspended for 30 days.
Parisse will be free to play again on 18 March, after seeing red last weekend playing for his club Stade Francais against Bordeaux-Begles when he was dismissed for allegedly insulting match referee Laurent Cardona.
The ban, 40 days with 10 suspeneded, rules him out of Italy's remaining RBS 6 Nations games this season against Wales, England and Ireland.
The No 8 was sent off after 36 minutes of Stade's home match with Bordeaux-Begles, having scored a try in the fourth minute.
Italy coach Jacques Brunel had already called veteran flanker Mauro Bergamasco into his squad to face Wales.
We look back on the victory over Fiji that makes it three from three for Wales in this World Cup, in a special extra Principality Welsh Rugby Union Podcast. We hear from Wales coach Warren Gatland, captain Sam Warburton, plus Gethin Jenkins, Tomas Francis, Alun Wyn Jones, Dan Biggar, Matthew Morgan and Tyler Morgan, as well as defence coach Shaun Edwards and getting the Fijian perspective from coach John McKee.
Birthday boy Hallam Amos gets the perfect present with his selection on the wing for Wales ahead of Alex Cuthbert as Warren Gatland's men prepare to face England at Twickenham tomorrow in a crucial pool game of the World Cup
Wales head coach Warren Gatland and captain Sam Warburton say their first prioirty on Sunday in the opening game of the World Cup is to win against Uruguay and not get overly concerned with points difference.
Captain Sam Warburton admits he is devastated for Rhys Webb and Leigh Halfpenny who will both miss the World Cup due to injury but he is confident Wales' strength in depth will see his side bounce back and mount a serious challenge.
Wales assistant coach Shaun Edwards says Wales will go into the World Cup still hurting from the semi-final defeat four years ago in New Zealand. But before that, there is the small matter of Italy, tomorrow at the Millennium Stadium.
Following the success of the inaugural All Schools Touch Championships (ASTC) held in July 2015, a new partnership has been announced with the Wales Touch Association to ensure that pupils throughout Wales are able to play in high-quality Touch events.
A combative Wales Girls team were unable to maintain momentum on the second day of action in the 7s Grand Prix Series in Liege, but head coach Rhys Edwards still left Belgium in a positive frame of mind.
Pupils from Ysgol Castell Nedd and Ysgol y Dderwen will be the first to compete for Welsh Schools titles at the Millennium Stadium this season when they run onto the hallowed turf of the Millennium Stadium tomorrow (Wednesday).