Iestyn Harris, Jamie Robinson, Craig Morgan and Ryan Powell have all been released from international camp to play for Cardiff in the Welsh Premiership match with Neath on Friday (kick off 7:05pm) at the Arms Park.
However Wales boss Steve Hansen has opted to keep club captain Martyn Williams and Rhys Williams within the international camp - neither being made available for the Arms Park clash.
Both players are the first choices in their respective positions, and will be allowed the weekend to rest ahead of next Saturday's potential Wooden spoon decider with Scotland.
Neath captain Gareth Llewellyn, who made a replacement's appearance against England, has also been granted permission to play.
Hooker Steve Jones will rejoin the full squad having returned from a neck injury.
Neath had been using prop Duncan Jones as a stand-in hooker, however he is unavailable after suffering knee ligament damage in the Welsh All Blacks recent Welsh Premiership victory against Llanelli. He faces a six week lay-off.
Cardiff: Craig Morgan; Nick Walne, Jamie Robinson, Pieter Muller, Anthony Sullivan; Iestyn Harris, Ryan Powell; John Yapp, Peter Rogers, Tim Payne, Heino Senekal, John Tait (captain), Dan McShane, Dan Baugh, Robin Sowden-Taylor
Replacements: Aled Jones, Greg Woods, Adam Jones, Luke Tait, Dean Dewdney, Nick Robinson, Donavan van Vuuren
Neath: 15 Adrian Durston 14 Kevin James 13 James Storey 12 Dave Tiueti 11 Shane Williams 10 Lee Jarvis 9 Patrick Horgan 8 Rowland Phillips 7 Jamie Ringer 6 Alfie Mocelutu 5 Gareth Llewellyn (c) 4 Steve Martin 3 Adam Jones 2 Steve Jones 1 Paul James