Newport and Wales centre Andy Marinos is fighting to recover from deep vein thrombosis.
The 30-year-old has the life threatening condition and only early detection has stopped it from claiming his leg.
And now Marinos faces a race against time to recover for the World Cup in Australia this October.
"I'm hoping to be play at least a month and a half of the season and try and stake a claim to get into the World Cup squad, but time is not on my side," admitted Marinos.
Marinos had already been ruled out of this year's Six Nations campaign after suffering damaged ligaments in his foot earlier in the season.
And despite his confidence that he will eventually return to full fitness Marinos has admitted that his leg could never fully recover from the condition also known as, "economy class syndrome," due to its association with long-distance travel.
He said: "Once you've damaged an artery in the leg it's never going to be the same again.
"I had anticipated being back in the middle of March but this is obviously a massive set back."
Marinos first made his Wales debut against Ireland in last season's Six Nations championship and was the highlight of an otherwise disappointing campaign for the Principality.
But even if he does recover from DVT his hopes to travel to Australia could be skuppered due to the connections between the condition and air travel.
And a 60 hour round-trip to Australia for the World Cup is unlikely to be beneficial for Marinos' leg.
However, the South African born star is still positive that he will be able to travel
"I've got to be sensible and manage it correctly on any long haul flights, said Marinos. "I've been advised to take some form of blood thinner to help me out."
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series