Wednesday will bring six matches with leaders Pontypool heading the list with a home match against Glamorgan Wanderers, who upturned Pooler earlier in the season.
Bedwas will hope to continue their good run at home to bottom club Treorchy, while Bonymaen entertain Newbridge in what could be a high-scoring affair and Llandovery should have an entertaining home match against Cross Keys.
Carmarthen Quins, who beat Aberavon by one point last Friday, will go to Whitland in search of another win and Tredegar are at home to Beddau, if the floodlights allow it.
Aberavon's home match against Narberth is on Friday evening (Feb 21), while Tondu's home match against Llanharan will also be played on that day - if their floodlights are repaired.
Also playing on Friday will be the Premiership match between Pontypridd and Caerphilly at Sardis Road (kick off 7.15pm)...