Holders Llanelli open their defence of the Konica Minolta Cup by breaking new ground when they travel to Brecon in the fourth round on Saturday, December 27.
Llanelli have won Welsh rugby's annual challenge cup 12 times, but have never met Brecon in the 33 seasons of the competition, despite the pair
first playing each other in January 1889.
Cardiff also have new opponents as they travel to Division One club Brynmawr. The Gwent club recently signed fly-half Jason Williams, the
highest-ever league scorer in Wales who has already scored 175 of his club's 290 points this season.
Of the 16 Premier sides entering the last 64, Cross Keys and Carmarthen Quins are paired at Pandy Park and Llandovery will entertain Neath at Church Bank.
The Cup also sees a return for former Wales League and Union scrum-half David Bishop to one of his old clubs. Bishop coaches and occasionally plays for the Old Illtydians on a Cardiff park, and they are drawn away to Ebbw Vale, where the Illtydians scored a memorable 14-11 Cup win in 1994-95.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series