Holders Llanelli open their defence of the Konica Minolta Cup by breaking new ground when they travel to Brecon in the fourth round on Saturday, December 27.
Llanelli have won Welsh rugby's annual challenge cup 12 times, but have never met Brecon in the 33 seasons of the competition, despite the pair
first playing each other in January 1889.
Cardiff also have new opponents as they travel to Division One club Brynmawr. The Gwent club recently signed fly-half Jason Williams, the
highest-ever league scorer in Wales who has already scored 175 of his club's 290 points this season.
Of the 16 Premier sides entering the last 64, Cross Keys and Carmarthen Quins are paired at Pandy Park and Llandovery will entertain Neath at Church Bank.
The Cup also sees a return for former Wales League and Union scrum-half David Bishop to one of his old clubs. Bishop coaches and occasionally plays for the Old Illtydians on a Cardiff park, and they are drawn away to Ebbw Vale, where the Illtydians scored a memorable 14-11 Cup win in 1994-95.
The Welsh Rugby Union has awarded a unique 'President's Cap' to a specific group of players who represented their country between 1945 and 1979, but missed out on international recognition at the time.
Prabhat Mathema, the WRU's National Medical Manager explains the four part Pitchside Suspected Concussion Assessment process the IRB has devised that is being implemented throughout the Dove Men Series and in the LV= Cup this season, which includes the provision for a five minute temporary substitution to allow an assessment to take place.