Holders Llanelli open their defence of the Konica Minolta Cup by breaking new ground when they travel to Brecon in the fourth round on Saturday, December 27.
Llanelli have won Welsh rugby's annual challenge cup 12 times, but have never met Brecon in the 33 seasons of the competition, despite the pair
first playing each other in January 1889.
Cardiff also have new opponents as they travel to Division One club Brynmawr. The Gwent club recently signed fly-half Jason Williams, the
highest-ever league scorer in Wales who has already scored 175 of his club's 290 points this season.
Of the 16 Premier sides entering the last 64, Cross Keys and Carmarthen Quins are paired at Pandy Park and Llandovery will entertain Neath at Church Bank.
The Cup also sees a return for former Wales League and Union scrum-half David Bishop to one of his old clubs. Bishop coaches and occasionally plays for the Old Illtydians on a Cardiff park, and they are drawn away to Ebbw Vale, where the Illtydians scored a memorable 14-11 Cup win in 1994-95.
Whenever Bedlinog tackle Penallta a massive fixure is guaranteed but this Sunday there will be even more emphasis placed on the two rivals when they contest the SSE Swalec Plate final at Principality Stadium.
Ahead of their SSE SWALEC Bowl Final clash with Taffs Well at Principality Stadium on Sunday, Burry Port share their #FABXV nomination with WRUTV in the search for Welsh rugby's greatest volunteers. Everyone can get involved by sending nominations via twitter to @WRU_Community using the hashtag #FABXV
Cardiff Blues prop Gethin Jenkins and Ospreys centre Ben John look ahead to the first game at Principality Stadium in Saturday's double header which is promising to be a special occasion for all Welsh fans.
Carmarthen Quins Director of Rugby Ian Jones and committee member Jeff Thomas along with Llandovery chairman Handel Davies look ahead to Sunday's SSE SWALEC Cup showdown where both teams are out to prove 'West is best'
SWALEC ambassador Shane WIlliams is looking forward to Sunday's Finals Day where the Cup, Bowl and Plate offers a great opportunity for players and teams to experience the magic of playing at Principality Stadium
Carmarthen Quins coach Richard Kelly believes it is an exciting time to be part of the Scarlets region as his side take on local rivals Llandovery in the SSE Swalec Cup final on Sunday, as WRU TV's Graeme Gillespie discovers