Second-placed Llanharan, top try scorers in the division with 89 touchdowns, have a tricky visit to third-placed Whitland to contend with and their unbeaten tag will be put to the test by the Borderers.
Struggling Tondu face a daunting task at Narberth, Tredegar play host to the students of UWIC, and Treorchy visit Blackwood who beat the Zebras 55-24 in their first meeting.
Abercynon are going great guns in Two East and Croesyceiliog will not relish paying them a visit particularly after 'Cynon's 54-0 victory last week at Penygraig. Merthyr and Builth Wells are in close pursuit of the leaders and Merthyr will be looking for victory when they travel to Risca, while the Bulls have a sterner test at Llantrisant.
New Two West leaders Cwmllynfell play host to Pencoed and second-placed Dunvant travel to Cardigan and both sides will be looking to put some daylight between themselves and the challenging sides.
Brynithel entertain Senghenydd in a top of the table battle in Three East. Llanishen could improve their position with a victory at Newport Saracens but the Saries themselves have an eye on promotion and this will be a tough game. Kidwelly are the team to beat in Three West. Last week they totted up their 13th straight league success and will be confident when they visit mid-table Lampeter. Treherbert were beaten for the first time last week in Three South East and they will be keen to get straight back on track as they entertain lowly Taffs Well, while Gilfach Goch could close up with victory at Pentyrch. Trebanos have their best opportunity of racking up their first win of the season in Three South West when they travel to fellow strugglers Ystradgynlais.
Top game in Division Four is at Alltwen where Taibach are the visitors in South West. In South East, Fairwater will want to keep their promotion hopes on line with victory over Pontyclun and at the bottom of this division Bedlinog will be looking for their second win of the season when they entertain Penarth.
Cefneithen are well clear at the top of Five West and a visit to St David's should keep them well clear of their challengers. St Albans are one of the few sides still without a point and they travel to Gwernyfed in Five East looking to kick-start their season.