In Division One leaders Maesteg entertain Tredegar, who also face a trip to Llanharan in a rearranged match next Tuesday evening. Llanharan will also be the hosts on Saturday when Blackwood are the visitors.
At the other end of the table Tondu meet Rumney in a must-win match for both clubs, while Treorchy have a hard task at Whitland and Glamorgan Wanderers can expect little from their trip to Narberth.
Bonymaen against Brynmawr is an intriguing battle at Parc Mawr, while
Carmarthen Athletic will not underestimate Beddau and Llangennech meet a UWIC side riddled with injuries.
In the much-troubled Division Two East have a huge match at Fleur de Lys, where the home side protect an unbeaten record as powerful Merthyr are visitors, while Rhymney against Abercynon promises a strong match between two old foes.
In the West, Corus are attractive visitors at Waunalwydd and Tonmawr will provide Cardigan with a good match, but the plumb game could be at Felinfoel where fast-improving Cwmllynfell will be hard to beat.