The competition kicks-off on the weekend of Saturday, 21 November, with SWALEC Cup winners Neath taking on Bristol Rugby at The Gnoll, Newport hosting Exeter Chiefs at Rodney Parade and the four other Principality Premiership clubs clashing in two mouth-watering Welsh derbies, Pontypridd at home to Cardiff while Llanelli welcome Aberavon to Parc y Scarlets.
In Round two the following weekend, three Welsh teams again have home advantage, Newport hosting Plymouth Albion, Aberavon entertaining London Welsh in a plum tie at the Talbot Athletic Ground and Pontypridd taking on Doncaster Knights. Cardiff, Llanelli and Neath travel to Birmingham & Solihull, Bedford Blues and Nottingham respectively.
Rounds Three, Four and Five take place during the Six Nations period, the first of which takes place on the weekend of 13 February when Wales clubs play Scottish and Irish opposition for the first time, Newport hosting Scotland's National Academy, Neath travelling to Heriots FP and Llanelli hosting Ulster. Pontypridd and Cardiff meanwhile take on English opposition away from home, Pontypridd at Rotherham Titans and Cardiff at Birmingham & Solihull.
Neath take on Munster on the weekend of 27 February while Newport travel to Leinster. Llanelli host Moseley and Cardiff welcome Rotherham Titans to the Arms Park while Pontypridd and Aberavon travel to Ayr and Bedford Blues respectively.
The final round of Pool games takes place on the weekend of 6 March or midweek on March 10 / 11. In a final bid to secure semi-final places, Newport will travel to Penzance to take on Cornish Pirates, Neath host Coventry, Llanelli travel to Richmond to play London Welsh, Aberavon travel to Belfast to challenge Ulster, and Pool D's Pontypridd and Cardiff travel to Birmingham & Solihull and Ayr respectively.
WRU Head of Rugby, Performance and Development Joe Lydon said: "We knew we could expect some high-calibre encounters at the very earliest stages of the competition but it's an added boost for the Welsh clubs to be able to kick-off their British and Irish Cup campaign on Welsh soil.
"The British and Irish Cup is an opportunity for us to develop more players to achieve their full potential and enable them to compete at the very highest level.
"Welsh rugby fans have traditionally savoured the sporting edge delivered by cross border games and this cup will give our Premier Division a fantastic lift onto the next level of competition."
Chris Clarke, chair of the Welsh Premier Division clubs added: "It is a very exciting time for everyone involved in Premiership club rugby. We feel this is a very positive move by the Welsh Rugby Union to get involved in this project and by the clubs who have given it their full support.
"It is a level of competition that has been called for by semi-professional clubs in Wales for some time, and its introduction will help bridge the gap towards professional, Regional rugby in Wales.
"We look forward to seeing this tournament kick-off and grow into something special."
Wales Under 18 captain Callum Bradbury is delighted to have seen his side claim a narrow 18-17 victory against a strong SA Schools 'A' side to end the three-match Under 19 International Series in South Africa on a high note.
The Wales U18 squad spent an emotional day in the drug-riddled townnship of Hout Bay. Hout Bay Warriors President Fred Johannes said the visit was 'the talk of the town' and will dream about the day everyday for the rest of his life.
RGC 1404's new head coach Mark Jones is hoping to build 'something special' in north Wales and is already looking forward to the development region participating in the Principality Premiership for the very first time.
A joint venture between the WRU and Admiral saw hundreds of children enjoy the Admiral Festival of Rugby held at the National Centre of Excellence at the weekend where Welsh internationals Sam Warburton, Scott Williams and Rob Evans were in attendance.
Wll Jones leads Wales U18s into battle this afternoon against Italy where the Welsh side will be seeking to bounce back from their narrow defeat to SA Schools in their opening clash of the U19 International Series
All four regions attended a successful training camp staged last weekend at the WRU National Centre of Excellence. It was a chance for new Wales Women's head coach Rowland Phillips to deliver his key messages to players and coaches as he prepares for the new season.
Wales U18 Team Manager Gethin Watts believes the next couple of weeks will be 'extremely beneficial' to the future of Welsh rugby as his side prepare to take part in the Under 19 International Series being staged in South Africa.
The WRU is searching for 12 new rugby development apprentices following a successful first year of its WRU Coach Core programme. Craig Duncan and Jess Hancock have flourished in the first year of the programme which has given them a real direction in their lives.
The WRU signed TV comedian Rhod Gilbert up to a 'Coaching Children Level 1' course before letting him loose on an U8s side at Whitland Junior Borderers - we went behind the scenes to film the making of 'Rhod Gilbert's Work Experience' see the results here.
Llandovery are aiming to make it three titles in a row in this year's Foster's National 7s being held at BT Sport Cardiff Arms Park on Sunday 28 August. Drovers assistant coach Simon Davies and Lee Rees assess their sides chances
A pioneering strength and conditioning programme has been delivered to more than 8000 boys and girls at hub schools throughout Wales this season, helping to develop stronger, more flexible athletes for rugby and other sports.
The Singha Premiership Rugby 7s Series returns to the BT Sport Cardiff Arms Park on July 22nd when all four Welsh regions go head to head. Scarlets skills coach Dai Flanagan and Blues Elite Performance Pathway Manager Richard Hodges along with current Welsh squad members were at the launch of this season's event