Out injured for Ponty are winger Chris Clayton, still troubled by an abdominal strain, hooker Leighton Davies with a calf strain, and lock Chris Martenko with a jarred neck. Flanker Rhys Lloyd will see out the last weekend of his compulsory rest
period following concussion.
Back in the frame are centre Adam Thomas, prop Pat Palmer and flanker Wayne O'Connor, having recovered from recent shoulder and rib injuries. Scrum half Rhys Downes and hooker Rhys Williams also return to club duties, taking a break from the Wales under 20s Six Nations' campaign.
Despite the recent lack of match practice, Ponty team manager Richard Langmead is confident that his players are ready to take up action stations with a bid for cup glory.
"The squad have trained well over the past week" said Langmead. "Going a few weeks without a fixture has proved to be an incentive for the boys to double their efforts, they have prepared well and are itching to go.
"We expect a totally different contest to the league match, with a far more difficult task to face, but we remain confident of making it into the next round of the cup".
The Pontypridd team selected to face Cross Keys is as follows:
15.Matthew Hutchings. 14.Kristian Baller. 13.Gavin Dacey. 12.Adam Thomas. 11.Owen Williams. 10.Gareth McCarthy. 9.Rhys Downes.
1.Stuart Williams. 2.Huw Dowden. 3.Pat Palmer. 4.Grant Harrington. 5.Chris Dicomidis. 6.Geraint Lewis. 7.Wayne O'Connor. 8.Nathan Strong - cpt.
Subs: Andrew Jenkins; Dai Flanagan; Lawrence Price; Rhys Williams; Kristian Dacey; Ryan Savage; Sam Hobbs.