Gavin Henson's injury jinx has struck Wales again on the eve of their Six Nations title defence.
Injury-plagued Henson was named to start the Wales opener against Scotland tomorrow (Sun) but has pulled out with a calf strain.
British Lion Tom Shanklin replaces Henson in the starting line-up at outside centre with Cardiff Blues team-mate Jamie Roberts switching to inside centre with Andrew Bishop coming onto the bench.
This is the latest set-back for the Wales and Ospreys star who has been dogged by problems both on and off the pitch.
Henson has made just nine starts in three years for Wales since damaging his shoulder playing for the British Lions in 2005.
Groin surgery and suspension hampered 2006 while a year later, the 26-year-old tore cruciate knee ligaments before missing out on the World Cup that year with an Achilles problem.
Henson returned from a broken hand to spearhead last year's Slam success only to sit out the next six months following ankle surgery.
He then withdrew on the eve of the 2008 autumn series after the Achilles problem reared up once again before this latest set-back.
Wales coach Warren Gatland kept his faith in Henson who has been a lucky charm in the Six Nations having never lost in ten championship games when he has started.
Gatland said: "Gavin just felt his calf tightening in training. There is no point making it a major problem that would keep him out for six or eight weeks."
Wales (v Scotland): Lee Byrne; Leigh Halfpenny, Tom Shanklin, Jamie Roberts, Shane Williams; Stephen Jones, Mike Phillips; Gethin Jenkins, Matthew Rees, Adam Jones, Ian Gough, Alun Wyn Jones, Ryan Jones (capt), Andy Powell, Martyn Williams. Replacements: John Yapp, Huw Bennett, Luke Charteris, Dafydd Jones, Dwayne Peel, James Hook, Andrew Bishop.
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.