Gavin Henson's injury jinx has struck Wales again on the eve of their Six Nations title defence.
Injury-plagued Henson was named to start the Wales opener against Scotland tomorrow (Sun) but has pulled out with a calf strain.
British Lion Tom Shanklin replaces Henson in the starting line-up at outside centre with Cardiff Blues team-mate Jamie Roberts switching to inside centre with Andrew Bishop coming onto the bench.
This is the latest set-back for the Wales and Ospreys star who has been dogged by problems both on and off the pitch.
Henson has made just nine starts in three years for Wales since damaging his shoulder playing for the British Lions in 2005.
Groin surgery and suspension hampered 2006 while a year later, the 26-year-old tore cruciate knee ligaments before missing out on the World Cup that year with an Achilles problem.
Henson returned from a broken hand to spearhead last year's Slam success only to sit out the next six months following ankle surgery.
He then withdrew on the eve of the 2008 autumn series after the Achilles problem reared up once again before this latest set-back.
Wales coach Warren Gatland kept his faith in Henson who has been a lucky charm in the Six Nations having never lost in ten championship games when he has started.
Gatland said: "Gavin just felt his calf tightening in training. There is no point making it a major problem that would keep him out for six or eight weeks."
Wales (v Scotland): Lee Byrne; Leigh Halfpenny, Tom Shanklin, Jamie Roberts, Shane Williams; Stephen Jones, Mike Phillips; Gethin Jenkins, Matthew Rees, Adam Jones, Ian Gough, Alun Wyn Jones, Ryan Jones (capt), Andy Powell, Martyn Williams. Replacements: John Yapp, Huw Bennett, Luke Charteris, Dafydd Jones, Dwayne Peel, James Hook, Andrew Bishop.
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series