Carmarthen Quins came within inches of causing an upset against SWALEC Cup holders Neath.
Quins winger Ryan Llewellyn crashed over for a dramatic try in stoppage time to bring the scoreline back to 22-20 in Neath's favour.
But they missed out on a shot at extra-time as Quins outside-half Gareth Cull saw his conversion attempt shave the post.
Centre Luke Ford's try for Neath eight minutes from time proved to be the match winner.
Division One West club Tonmawr also failed to take their chance of an upset, losing 23-16 at home to Premiership Glamorgan Wanderers.
With the game locked at 16-16, Wanderers capitalised on the sin-binning of hooker Rhys Lawrence as winger Jamie Jones scored the game winning try with ten minutes left.
Llantwit Fardre, the lowest ranked team left in the competition, could not fashion a shock as they were hammered 74-0 at Aberavon.
The Division Three South East leaders, who had been unbeaten in 18 games, were sent crashing out by the Premiership side who scored 11 tries, including two each for centre Richard Thomas and No8 Rory Gallacher.
Caerphilly are now the only non-Premiership club remaining in the Swalec Cup after they won an all-Division One East tie at Rumney 17-12.
Outside-half Dan Ellis scored the Cheesemen's only try and kicked the rest of their points.
In three all-Premiership clashes, Cross Keys edged out Pontypridd 27-26, Swansea won at Ebbw Vale 23-13 and Newport beat Llandovery 38-18.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.