Carmarthen Quins came within inches of causing an upset against SWALEC Cup holders Neath.
Quins winger Ryan Llewellyn crashed over for a dramatic try in stoppage time to bring the scoreline back to 22-20 in Neath's favour.
But they missed out on a shot at extra-time as Quins outside-half Gareth Cull saw his conversion attempt shave the post.
Centre Luke Ford's try for Neath eight minutes from time proved to be the match winner.
Division One West club Tonmawr also failed to take their chance of an upset, losing 23-16 at home to Premiership Glamorgan Wanderers.
With the game locked at 16-16, Wanderers capitalised on the sin-binning of hooker Rhys Lawrence as winger Jamie Jones scored the game winning try with ten minutes left.
Llantwit Fardre, the lowest ranked team left in the competition, could not fashion a shock as they were hammered 74-0 at Aberavon.
The Division Three South East leaders, who had been unbeaten in 18 games, were sent crashing out by the Premiership side who scored 11 tries, including two each for centre Richard Thomas and No8 Rory Gallacher.
Caerphilly are now the only non-Premiership club remaining in the Swalec Cup after they won an all-Division One East tie at Rumney 17-12.
Outside-half Dan Ellis scored the Cheesemen's only try and kicked the rest of their points.
In three all-Premiership clashes, Cross Keys edged out Pontypridd 27-26, Swansea won at Ebbw Vale 23-13 and Newport beat Llandovery 38-18.
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.