Wales full back Lee Byrne has lost his battle to help the Ospreys face Munster in the Heineken Cup quarter-finals this weekend.
Byrne failed a fitness test in the Welsh region's final training session today and has been ruled out of Sunday's sell-out clash in Limerick.
Byrne damaged ligaments in his left foot during the Six Nations clash between Wales and Ireland and has not played since. He hopes to be available to play again within a few weeks.
Also missing from the Ospreys line-up is another of their British & Irish Lions contenders, Gavin Henson. He is now two weeks into his recuperation after twisting his ankle in the EDF Energy Cup semi-final defeat to Gloucester.
That caused damage to his ligaments on both the lateral and medial sides of his right ankle and he is likely to be
sidelined for at least another month.
Warren Gatland and Sam Warburton look ahead to this week's crunch RBS 6 Nations tie against France, where the Wales skipper in particular is keen to make his mark, as Paris has proved a bleak place for him in the past.
Following their historic win over England, Wales Under 20 suffered a narrow, 36-34 loss to their Scottish counterparts last weekend, despite outscoring them by five tries to three. Watch the match highlights and reaction.
WRU TV go behind the scenes with the Wales squad as they put the final touches in place ahead of the clash against Scotland at Murrayfield. Follow the squad on their captain's run, the kickers visit to Murrayfield and Neil Jenkins' press conference