Wales full back Lee Byrne has lost his battle to help the Ospreys face Munster in the Heineken Cup quarter-finals this weekend.
Byrne failed a fitness test in the Welsh region's final training session today and has been ruled out of Sunday's sell-out clash in Limerick.
Byrne damaged ligaments in his left foot during the Six Nations clash between Wales and Ireland and has not played since. He hopes to be available to play again within a few weeks.
Also missing from the Ospreys line-up is another of their British & Irish Lions contenders, Gavin Henson. He is now two weeks into his recuperation after twisting his ankle in the EDF Energy Cup semi-final defeat to Gloucester.
That caused damage to his ligaments on both the lateral and medial sides of his right ankle and he is likely to be
sidelined for at least another month.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.