Hosts Scotland face auld enemy England in their pool on day one, while World Series leaders South Africa have been handed the toughest of challenges in their pool against defending champions New Zealand.
Paul Treu's Boks currently lead the race for the overall title by 28 points from second-placed England and look well set to land a first ever IRB Sevens crown but any slip-up at Twickenham the previous weekend would make their Pool A challenge against the Kiwis, France and USA even more daunting.
Hong Kong Sevens champions Fiji line up at Murrayfield as second seeds and top Pool B with matches against Australia and Iberian neighbours Portugal and Spain.
Kenya, currently ranked sixth in the world after reaching three Cup semi finals this season and one final in Adelaide, top Pool C and face England, Scotland and Canada.
Argentina are the top seeds in Pool D, the Rugby World Cup Sevens runners-up drawn against Samoa, Georgia and World Champions Wales.
"The scene is set for an incredible climax to this 10th Anniversary IRB Sevens World Series in Scotland, the home of Sevens rugby," said IRB Sevens Manager Beth Coalter.
"South Africa have been outstanding this season and have certainly put themselves into the strongest of positions to clinch a historic first ever Series.
"The rugby has been so competitive this year, though, with so many teams capable of pulling off shock wins - there may yet be a twist in the tail."
With 104 points South Africa currently lead England (76) by 28 but the battle for second place is fierce with Fiji (74), Argentina (68), New Zealand (64) and Kenya (58) all still in contention.
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series