Hosts Scotland face auld enemy England in their pool on day one, while World Series leaders South Africa have been handed the toughest of challenges in their pool against defending champions New Zealand.
Paul Treu's Boks currently lead the race for the overall title by 28 points from second-placed England and look well set to land a first ever IRB Sevens crown but any slip-up at Twickenham the previous weekend would make their Pool A challenge against the Kiwis, France and USA even more daunting.
Hong Kong Sevens champions Fiji line up at Murrayfield as second seeds and top Pool B with matches against Australia and Iberian neighbours Portugal and Spain.
Kenya, currently ranked sixth in the world after reaching three Cup semi finals this season and one final in Adelaide, top Pool C and face England, Scotland and Canada.
Argentina are the top seeds in Pool D, the Rugby World Cup Sevens runners-up drawn against Samoa, Georgia and World Champions Wales.
"The scene is set for an incredible climax to this 10th Anniversary IRB Sevens World Series in Scotland, the home of Sevens rugby," said IRB Sevens Manager Beth Coalter.
"South Africa have been outstanding this season and have certainly put themselves into the strongest of positions to clinch a historic first ever Series.
"The rugby has been so competitive this year, though, with so many teams capable of pulling off shock wins - there may yet be a twist in the tail."
With 104 points South Africa currently lead England (76) by 28 but the battle for second place is fierce with Fiji (74), Argentina (68), New Zealand (64) and Kenya (58) all still in contention.
Young referee Ben Breakspear is making rapid strides as a referee. In just over a year he has gone from officiating a college game to being a touchline official during last weekend's RBS 6 Nations clash between Wales and Ireland at Principality Stadium.
Grand Slams, Triple Crowns and British and Irish Lions tours - Sir Gareth Edwards did it all. But what are his favourite moments in what was an amazing career? WRU TV finds out - along with his favourite players of today in the third and final instalment of our series with the greatest rugby player ever.
JPR Williams, Gerald Davies and Mervyn Davies were among those in the Welsh ranks when Sir Gareth Edwards began his international career against France nearly 50 years ago, but who was the player who took the young scrum half under their wing?
Wales head coach Rob Howley and captain Alun Wyn Jones are expecting a physical battle against France on Saturday but both are hoping for another impact from the bench as the men in red chase a top-four world ranking.
It's nearly 50 years since the great Sir Gareth Edwards made his debut as a youngster for Wales against France in Stade Colombes. In the first of a series, WRU TV discovers he pocketed a 'special momento' from the game - something he still has today.
This week, Wales squad players Sam Warburton, Jonathan Davies and Ken Owens took time out to support Operation Net Safe, a joint initiative by the four Welsh police forces to tackle child sexual abuse. The forces are working with the Lucy Faithfull Foundation, the only UK-wide child protection charity dedicated solely to reducing the risk of children being sexually abused, on a campaign called Stop it Now!