Hosts Scotland face auld enemy England in their pool on day one, while World Series leaders South Africa have been handed the toughest of challenges in their pool against defending champions New Zealand.
Paul Treu's Boks currently lead the race for the overall title by 28 points from second-placed England and look well set to land a first ever IRB Sevens crown but any slip-up at Twickenham the previous weekend would make their Pool A challenge against the Kiwis, France and USA even more daunting.
Hong Kong Sevens champions Fiji line up at Murrayfield as second seeds and top Pool B with matches against Australia and Iberian neighbours Portugal and Spain.
Kenya, currently ranked sixth in the world after reaching three Cup semi finals this season and one final in Adelaide, top Pool C and face England, Scotland and Canada.
Argentina are the top seeds in Pool D, the Rugby World Cup Sevens runners-up drawn against Samoa, Georgia and World Champions Wales.
"The scene is set for an incredible climax to this 10th Anniversary IRB Sevens World Series in Scotland, the home of Sevens rugby," said IRB Sevens Manager Beth Coalter.
"South Africa have been outstanding this season and have certainly put themselves into the strongest of positions to clinch a historic first ever Series.
"The rugby has been so competitive this year, though, with so many teams capable of pulling off shock wins - there may yet be a twist in the tail."
With 104 points South Africa currently lead England (76) by 28 but the battle for second place is fierce with Fiji (74), Argentina (68), New Zealand (64) and Kenya (58) all still in contention.
The WRU has launched a campaign to create a long term legacy for Welsh club rugby by highlighting the advantages of volunteering. Rhian Edwards, a volunteer at Seven Sisters, has enjoyed many benefits of her volunteering at a grassroots rugby club including being part of the Rugby World Cup volunteer workforce after being nominated by the WRU - and the WRU is asking for more people to develop their 'Welsh rugby roots'.
Wales head coach Warren Gatland and captain Sam Warburton say their first prioirty on Sunday in the opening game of the World Cup is to win against Uruguay and not get overly concerned with points difference.
With only days to go until the biggest rugby competition in the world begins, rugby fans visiting Cardiff this autumn will be able to enjoy a special display at National Museum Cardiff as part of the celebrations surrounding the Rugby World Cup.
Geraint John has taken up the new role of WRU elite coach development manager having arrived in Wales last week. WRU TV caught up with him at the WRU rugby department's strategy day at the Millennium Stadium.
The entire Welsh Rugby Union Rugby Department gathered at the Millennium Stadium earlier this week where WRU Head of Rugby Josh Lewsey looked back on a year where structural and strategic changes have seen significant progress made
The Welsh Rugby Union has released a specially produced video to spearhead a new campaign to help promote the values of rugby union. The video, entitled Let us Play underpins the WRU rugby department's philosophy - to engage, transfer and retain players, coaches and referees.