Duncan Jones is one of three changes to the Ospreys line-up.
Duncan Jones returns to the starting line-up for the first time in six months for the Ospreys, who host the Newport Gwent Dragons at the Liberty Stadium (tonight, 7.05pm kick-off).
Jones had been sidelined with a foot injury since October before coming off the bench to play the last 20 minutes of the Ospreys' 32-30 defeat to Edinburgh on Saturday.
He is one of three changes in Scott Johnson's team, all of which come in the forwards division. Paul James drops to the bench to accommodate loosehead prop Jones, his Welsh team-mate Alun-Wyn Jones returns in the second row, replacing of Andy Lloyd, and Marty Holah comes in at openside flanker in place of Steve Tandy.
The Ospreys will be looking to lift their home support after the Edinburgh defeat all but mathematically ended their chances of catching Munster at the top of the Magners League.
Coach Sean Holley said: "We owe it to our supporters to go out on a high, so we will be giving it everything to try and give them the performance that they expect.
"Although we accept it is now unlikely that we will be able to overcome Munster at the top of the table, there is still a lot to play for."
Meanwhile, the Dragons are part of a three-way battle to avoid finishing as the lowest-placed Welsh region, meaning they would face a Heineken Cup play-off.
Paul Turner has made five changes from the team that beat Connacht 27-14 at Rodney Parade on Sunday. Rory Sidey comes in for Ashley Smith at centre, Aled Brew replaces Richard Fussell on the left wing and Shaun Connor starts at outside-half in place of James Arlidge.
Up front, Steve Jones is at hooker, while Jamie Ringer takes over from Richard Parks at openside flanker. Captain Tom Willis, who drops to the bench to make way for Jones, said: "The play-off is not something we want to discuss much around here.
"If we take things one step at a time, hopefully Heineken Cup qualification will take care of itself."
Both teams have huge injury lists, with Colin Charvis, Kevin Morgan, Marc Stchrebina, James Harris, James Lewis, Duane Goodfield and Sean Tomes absent for the Dragons.
The Ospreys are without Gavin Henson, Sonny Parker, Jamie Nutbrown and Rhodri Wells, while Jonathan Thomas, Ian Evans, Nikki Walker, Ben Lewis, Lyndon Batemen and Kristian Phillips.
Ospreys: Lee Byrne, Tommy Bowe, James Hook, Andrew Bishop, Shane Williams, Dan Biggar, Mike Phillips; Duncan Jones, Huw Bennett, Adam Jones, Filipo Levi, Alun Wyn Jones, Tom Smith, Marty Holah, Ryan Jones (C).
Replacements: Ed Shervington, Paul James, Ian Gough, Filo Tiatia, Tavis Knoyle, Jonathan Spratt, Gareth Owen.
Dragons: Jason Tovey, Gareth Wyatt, Rhodri Gomer Davies, Rory Sidey, Aled Brew, Shaun Connor, Wayne Evans; Adam Black, Steve Jones, Rhys Thomas, Hoani Macdonald, Luke Charteris (C), Danny Lydiate, Jamie Ringer, Joe Bearman.
Replacements: Tom Willis, Nigel Hall, Hugh Gustafson, Lewis Evans, Andrew Hall, Phillip Dollman, Alex Walker.
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.