World Cup Sevens winner Aled Brew makes his return to the Newport Gwent Dragons on Friday (6.30pm kick-off) as the Welsh region travel to Galway to face Connacht.
Brew, who won the World Cup alongside Dragons teammates Tom Isaacs and Tal Selley in Dubai last month, makes a competitive debut in his second spell at the region, having spent the 2006/07 season there on loan from the Ospreys.
Brew rejoined the Dragons from the Cardiff Blues in January, initially coming in on-loan until the end of the season before a one year permanent contract comes into effect from June.
Fellow Wales Sevens star Isaacs has withdrawn from the squad due to a hip injury, and joins a lengthy Dragons injury list of Rhodri Gomer-Davies, Adam Black, James Harris, Gareth Wyatt and Marc Stchrebina.
Welsh international Luke Charteris returns to the Dragons starting XV for the first time since the Six Nations, as do Hugh Gustafson, Hoani Macdonald and Richard Fussell.
Dragons coach Paul Turner has no illusions about the windy playing conditions at the Sportsground, where his side have not won since May 2004.
He said: "We are well aware of our record in Galway and what a difficult place it is to go to.
"Connacht have already beaten Leinster and Munster at home this season and probably two or three of the regional sides have been on the brink of defeat there."
Turner added: "This game will be a good challenge for us and our development if we want to move up the table.
"If we have any pretence of going into the top four in the Magners League we have to win in Galway."
Michael Bradley makes four changes to his Connacht side, with centre Niva Ta'auso and scrum-half Frank Murphy both overcoming injuries to return in the backline.
Up front, prop Ronan Loughney and flanker Johnny O'Connor come into the side. There are also a number of positional changes from last Friday's 32-5 loss at Edinburgh, as Gavin Duffy switches from the centre to full-back, Andrew Browne moves into the second row and Ray Ofisa makes his first start at number eight.
Dragons Kevin Morgan, Richard Fussell, Rory Sidey, Ashley Smith, Aled Brew, Jason Tovey, Wayne Evans, Hugh Gustafson, Tom Willis (Capt), Rhys Thomas, Sean Tomes, Luke Charteris, Hoani Macdonald, Richard Parks, Joe Bearman,
Replacements Steve Jones, Nigel Hall, Adam Jones, Danny Lydiate, Martyn Thomas, Shaun Connor, Robert Lewis,
Connacht team: G Duffy; F Carr, N Ta'auso, K Matthews, L Bibo; I Keatley, F Murphy; B Wilkinson, S Cronin, R Loughney; A Browne, A Farley; J Muldoon (C), J O'Connor, R Ofisa.
Replacements: A Flavin, B McGovern, M Swift, C Rigney, C O'Loughlin, A Dunne, T Nathan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series