The Ospreys will be looking to bounce back from their 17-0 loss to Gloucester in the EDF Energy Cup by getting back on track in the Magners League at Ulster, but will be without a number of internationals.
The region were hit by a double blow this week, with Wales pair Gavin Henson and Jonathan Thomas being ruled out for the rest of the season.
Flanker Thomas has suffered a recurrence of a long-term groin problem, and has been advised to take three months recovery, while centre Henson was withdrawn during Saturday's semi-final against Gloucester and will out until early May.
Ian Gough was also taken off against Gloucester, suffering a haematoma in his hip, and will miss the Ulster clash but hopes to be fit for next weekend's match with Munster in the Heineken Cup quarter-final.
Lee Byrne remains on the sidelines as he recovers from damaged ligaments suffered in Wales's Six Nations finale against Ireland, while two other Welsh internationals in Shane Williams and captain Ryan Jones will not travel with the side to Northern Ireland.
Host Ulster had found form during the Six Nations break, having won both of their matches in this period, although like the Ospreys lost to Leinster in their last Magners League game.
Coach Matt Williams will be without Stephen Ferris, Bryn Cunningham and Paul Steinmetz but can call upon NiallO'Connor and Mark McCrea, who have been added to the squad for Friday night. And Williams is taking nothing for granted despite the Welsh region's weakened state.
"The Ospreys are a fantastic team and physically massive. No-one expects us to win so there isn't much pressure on us," said Williams.
"They are individually the best team in the competition with a big squad of very high quality players so it could be our toughest game at Ravenhill this season."
Forwards: Brendon Botha, Tom Court, Bryan Young, Ed O'Donoghue, Matt McCullough, Carlo del Fava, Chris Henry, Nigel Brady, David Pollock, Rory Best, Ryan Caldwell, Robbie Diack.
Backs: Simon Danielli, Andrew Trimble, Darren Cave, Cillian Willis, Niall O'Connor, Clinton Schifcofske, Ian Whitten, Isaac Boss, Ian Humphreys, Timoci Nagusa, Mark McCrea, Paddy Wallace.
Ospreys : Gareth Owen; David Bishop, Jonathan Spratt, Andrew Bishop, Jonny Vaughton; James Hook, Mike Phillips; Paul James (capt), Huw Bennett, Cai Griffiths, Alun Wyn Jones, Andy Lloyd, Tom Smith, Steve Tandy, Filo Tiatia.
Replacements: Richard Hibbard, Ryan Bevington, Filipo Levi, Marty Holah, Jamie Nutbrown, Dan Biggar, Sonny Parker.
WRU TV were on hand at the launch of a major new commercial deal with WRU and Mercedes-Benz South Wales (part of the Sinclair Group), which sees the family company become an official supplier to the Welsh Rugby Union
On the back of the recent Women's Rugby World Cup, the WRU has launched a revitalised Women's and Girls domestic seasonal structure, and the future is looking bright.
Go to www.wru.co.uk/tryourgame for more information
Roger Lewis talks to WRU TV at the announcement of a new £60 million Rugby Services Agreement (RSA) which provides a new and positive contractual relationship between the WRU and its four Regions for the next six years has been agreed.
The Welsh Rugby Union has announced a major new sponsorship deal with Gullivers Sports Travel which will make the UK's leading, and longest established, multi-sport tour operator, an Official Supplier for the rest of the decade.
Having taken part in seven World Cups as a player and coach, Liza Burgess hopes to go out in style this afternoon when Wales take on Australia in the Play-off for seventh and eighth place in the Women's Rugby World Cup in Paris.