The Ospreys will be looking to bounce back from their 17-0 loss to Gloucester in the EDF Energy Cup by getting back on track in the Magners League at Ulster, but will be without a number of internationals.
The region were hit by a double blow this week, with Wales pair Gavin Henson and Jonathan Thomas being ruled out for the rest of the season.
Flanker Thomas has suffered a recurrence of a long-term groin problem, and has been advised to take three months recovery, while centre Henson was withdrawn during Saturday's semi-final against Gloucester and will out until early May.
Ian Gough was also taken off against Gloucester, suffering a haematoma in his hip, and will miss the Ulster clash but hopes to be fit for next weekend's match with Munster in the Heineken Cup quarter-final.
Lee Byrne remains on the sidelines as he recovers from damaged ligaments suffered in Wales's Six Nations finale against Ireland, while two other Welsh internationals in Shane Williams and captain Ryan Jones will not travel with the side to Northern Ireland.
Host Ulster had found form during the Six Nations break, having won both of their matches in this period, although like the Ospreys lost to Leinster in their last Magners League game.
Coach Matt Williams will be without Stephen Ferris, Bryn Cunningham and Paul Steinmetz but can call upon NiallO'Connor and Mark McCrea, who have been added to the squad for Friday night. And Williams is taking nothing for granted despite the Welsh region's weakened state.
"The Ospreys are a fantastic team and physically massive. No-one expects us to win so there isn't much pressure on us," said Williams.
"They are individually the best team in the competition with a big squad of very high quality players so it could be our toughest game at Ravenhill this season."
Forwards: Brendon Botha, Tom Court, Bryan Young, Ed O'Donoghue, Matt McCullough, Carlo del Fava, Chris Henry, Nigel Brady, David Pollock, Rory Best, Ryan Caldwell, Robbie Diack.
Backs: Simon Danielli, Andrew Trimble, Darren Cave, Cillian Willis, Niall O'Connor, Clinton Schifcofske, Ian Whitten, Isaac Boss, Ian Humphreys, Timoci Nagusa, Mark McCrea, Paddy Wallace.
Ospreys : Gareth Owen; David Bishop, Jonathan Spratt, Andrew Bishop, Jonny Vaughton; James Hook, Mike Phillips; Paul James (capt), Huw Bennett, Cai Griffiths, Alun Wyn Jones, Andy Lloyd, Tom Smith, Steve Tandy, Filo Tiatia.
Replacements: Richard Hibbard, Ryan Bevington, Filipo Levi, Marty Holah, Jamie Nutbrown, Dan Biggar, Sonny Parker.
The Welsh Rugby Union is forming a new Youth Board with a brief to help keep more young people involved in the game during their late teenage years and beyond. The first task of the fifteen strong Board will be to analyse and consider the issues which lead to a number of youngsters drifting away from the sport between the ages of 16 and 21. To apply visit www.wru.wales/youthboard
The Foster's Challenge Cup will involve the 12 Principality Premiership sides and will run during European and British & Irish Cup weeks, providing vital fixtures for the participating clubs and an opportunity for upcoming players to step up to semi-professional rugby and make a claim for starting places within the Premiership squads.
Eighty schools and colleges in Wales now have a full time rugby officer as part of the WRU's school club hub scheme. All of the school club hub officers recently gathered at the National Centre of Excellence for various workshops.
With Liam Williams forced out of the World Cup through injury, lock Luke Charteris and Skills Coach Neil Jenkins say they have to put yesterday's defeat behind them as Wales now look ahead to another physical encounter against South Africa in the quarter-finals of the Rugby World Cup.
WRU Consultant Head of Physical Performance Paul Stridgeon praises the Physical Performance department for their work and dedication as he addresses the media ahead of Wales' Pool A clash against Australia
Twelve young people have been selected to follow a one year WRU Coach Core apprenticeship programme. Coach Core was set up by the Royal Foundation of the Duke and Duchess of Cambridge and Prince Harry as part of the Olympics legacy in 2012 and the Duke of Cambridge was on hand to meet the apprentices on their first day in the job. The programme has been funded by the Hunter Foundation.
The WRU has launched a campaign to create a long term legacy for Welsh club rugby by highlighting the advantages of volunteering. Rhian Edwards, a volunteer at Seven Sisters, has enjoyed many benefits of her volunteering at a grassroots rugby club including being part of the Rugby World Cup volunteer workforce after being nominated by the WRU - and the WRU is asking for more people to develop their 'Welsh rugby roots'.