Hooker Matthew Rees and fly halff Stephen Jones have both been named by head coach Nigel Davies in his starting XV. Also back for action is fit-again centre Gavin Evans with Rob Higgitt moving to the bench.
Jones captains the team in place of Simon Easterby who is recovering from knee surgery.
Davies said: "We can expect a huge challenge at the RDS. Leinster had a fabulous victory last weekend in the Heineken Cup semi-final against Munster. It was a smashing game of rugby and they were very impressive indeed. The have a strong forward platform this season which, perhaps, they've struggled with in years gone by and they can front up in that area.
"They've always had the quality backs who can damage teams. They have a lot of experience and they've benefited from a consistency of selection this season."
Tomorrow's game is the first of three the Scarlets play in eight days to end their league campaign. Davies added: "It's a bit bizarre. We started the season with three games in a week and end it the same way - it means that, effectively, a third of our season is sorted out within two weeks.
"It's not ideal but everybody's got to face it and deal with it, particularly the teams that have progressed in Europe and in the Anglo-Welsh cup competition. It's got to be looked at because six games in two weeks isn't what anybody really wants. However, we've focused well this week and our aim is to go and win our final three games."
Leinster have made two changes to the team that stunned Munster last weekend. Jonathan Sexton, who came on for Felipe Contepomi in the titanic struggle, and Sean O'Brien start at outside half and in the back-row respectively.
Sexton partners Chris Whitaker at half-back, with O'Brien coming into a strong pack which includes Ireland internationals Bernard Jackman, Leo Cullen, Malcolm O'Kelly, Shane Jennings and Jamie Heaslip.
LEINSTER: 15: Isa Nacewa 14: Shane Horgan 13: Brian O'Driscoll 12: Gordon D'Arcy 11: Luke Fitzgerald 10: Jonathan Sexton 9: Chris Whitaker 1: Cian Healy 2: Bernard Jackman 3: Stan Wright 4: Leo Cullen CAPTAIN 5: Malcolm O'Kelly 6: Sean O'Brien 7: Shane Jennings 8: Jamie Heaslip
Subs: 16: John Fogarty 17: Ronan McCormack 18: Devin Toner 19: Stephen Keogh 20: Simon Keogh 21: Fergus McFadden 22: Girvan Dempsey.
Scarlets 15 Daniel Evans, 14 Mark Jones, 13 Gavin Evans, 12 Jon Davies, 11 Lee Williams, 10 Stephen Jones (c), 9 Martin Roberts, 1 Iestyn Thomas, 2 Matthew Rees, 3 Phil John, 4 Vernon Cooper, 5 Dominic Day, 6 Josh Turnbull, 7 Johnathan Edwards, 8 David Lyons.
Subs: 16 Deacon Manu, 17 Ken Owens, 18 Lou Reed, 19 Rob McCusker, 20 Gavin Cattle, 21 Rhys Priestland, 22 Rob Higgitt.

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