Tom Evans and Mike Grimes are out of the pack and in come Richard Thomas and Lee Highgate.
On the bench Matt Trowbridge returns after missing two games through injury and scrum half Rhys Dyer gets a place in the squad for the first time this season.
Dan Fish, who has impressed everyone this season, continues at fullback and he has been rewarded for his efforts with a place at the Blues academy.
Glamorgan Wanderers: 15. Dan Fish 14. Rory Budina 13. Charlie Johnson 12. Robin Lock 11. Ryan Healey 10. Scott Sneddon 9. Harry Trelawny; 1. Nathan Trevett 2. Ieuan Davies 3. Scott Andrews (capt) 4. Richard Thomas 5. Gareth Knight 6. Lee Highgate 7. Ben Rose 8. Josh Navidi
Replacementa: 16. Ieuan Dobbs 17. Mark O'Leary 18. Dan Partridge 19. Carl Kimber 20. Lee Highgate 21. Steve Cullen 22. Rhys Dyer