Jonathan Thomas returns to action after seven months out through a groin injury, and is joined among the replacements by British & Irish Lion Tommy Bowe, who will make his first appearance of the season if he comes on from the bench.
Sonny Parker comes into the squad to replace Jonathan Spratt, who has shown signs of fatigue in training this week and has been rested. He is expected to train as normal over the coming week and will be available for selection next weekend.
Ospreys coach Jonathan Humphreys commented: "We welcome back Jonathan Thomas after a lengthy lay-off and it's great to see him back again, he's had a pretty frustrating time of it but he's on the comeback trail which is great news. Likewise, with Tommy returning to action after the Lions tour, it's good to see the options available to us as coaches increasing.
"We're pretty satisfied with the result in Connacht last week, to come away from what is a difficult place with a win. It could have been far worse, there were some surprising results in the first week. It was our intention to get off to a positive start and we did that. There's still a lot for us to work on, which is quite pleasing really, we don't want to be hitting the ground at 100 per cent, we are building into it and as the season progresses we'll pick up the percentages as we go.
"We've looked at the video of last weekend's game, we've worked hard to improve in certain areas, and I'd expect to see us stepping up a level on Saturday evening. We want to go out on Saturday and send the right messages out to our supporters, in terms of what we want to achieve this season. We're very excited about coming back for the start of the season and it'll be great to see a big crowd waiting for us.
"As long as our mentality is right, as long as we show the pride I expect in the performance for the first home game and set the standards, we'll be alright and it will set us off in good stead for the rest of the season. The rest will follow."
Ospreys: 15 Barry Davies 14 Jonny Vaughton 13 Sonny Parker 12 Andrew Bishop 11 Nikki Walker 10 James Hook 9 Mike Phillips; 1 Paul James 2 Richard Hibbard 3 Cai Griffiths 4 Ian Gough 5 Andy Lloyd 6 Jerry Collins 7 Marty Holah 8 Ryan Jones (capt)
Replacements: 16 Huw Bennett 17 Duncan Jones 18 Jonathan Thomas 19 Tom Smith 20 Jamie Nutbrown 21 Dan Biggar 22 Tommy Bowe
Welsh players and management joined Deputy Minister for Sport Ken Skates at the Pierhead Building, Cardiff Bay earlier this week to reveal the Union's pioneering school-club hub initiative has been so successful the project will now almost double the scale of the original project.
The Scarlets, Newport Gwent Dragons, Cardiff Blues and the Ospreys look ahead to Judgement Day III which sees the Blues take on the Ospreys (2.30) and the Dragons tackle the Scarlets (4.45pm) at the Millennium Stadium tomorrow afternoon.
Ystradgynlais and Ynysddu played out a titanic struggle at Taffs Well in the SSE SWALEC Bowl semi-final. At the end of the game neither team could be separated after a 15-15 stalemate but Ystradgynlais go through on try count.
Blues strike first in JD III battle - Newport Gwent Dragons lock Andrew Coombs, WRU referee Dylan Llyr Jones and Cardiff Blues hooker Matthew Rees decide dressing room allocations for Judgement Day III
Wales Under 18 captain Calum Haggett has received a conditional offer to read Biomedical Science at St Anne's College, Oxford. WRU chairman Gareth Davies went to meet Calum and Coleg y Cymoedd Principal Judith Evans to wish him luck in his exams and pass on some of his personal experience.
Dodgy tattoos, carthorses, Avatar and soft chins are revealed by Wales Sevens players Tom Williams and Sam Cross as they profile the Wales Sevens squad taking part in Hong Kong this weekend in the latest round of the HSBC Sevens World Series.