Jonathan Thomas returns to action after seven months out through a groin injury, and is joined among the replacements by British & Irish Lion Tommy Bowe, who will make his first appearance of the season if he comes on from the bench.
Sonny Parker comes into the squad to replace Jonathan Spratt, who has shown signs of fatigue in training this week and has been rested. He is expected to train as normal over the coming week and will be available for selection next weekend.
Ospreys coach Jonathan Humphreys commented: "We welcome back Jonathan Thomas after a lengthy lay-off and it's great to see him back again, he's had a pretty frustrating time of it but he's on the comeback trail which is great news. Likewise, with Tommy returning to action after the Lions tour, it's good to see the options available to us as coaches increasing.
"We're pretty satisfied with the result in Connacht last week, to come away from what is a difficult place with a win. It could have been far worse, there were some surprising results in the first week. It was our intention to get off to a positive start and we did that. There's still a lot for us to work on, which is quite pleasing really, we don't want to be hitting the ground at 100 per cent, we are building into it and as the season progresses we'll pick up the percentages as we go.
"We've looked at the video of last weekend's game, we've worked hard to improve in certain areas, and I'd expect to see us stepping up a level on Saturday evening. We want to go out on Saturday and send the right messages out to our supporters, in terms of what we want to achieve this season. We're very excited about coming back for the start of the season and it'll be great to see a big crowd waiting for us.
"As long as our mentality is right, as long as we show the pride I expect in the performance for the first home game and set the standards, we'll be alright and it will set us off in good stead for the rest of the season. The rest will follow."
Ospreys: 15 Barry Davies 14 Jonny Vaughton 13 Sonny Parker 12 Andrew Bishop 11 Nikki Walker 10 James Hook 9 Mike Phillips; 1 Paul James 2 Richard Hibbard 3 Cai Griffiths 4 Ian Gough 5 Andy Lloyd 6 Jerry Collins 7 Marty Holah 8 Ryan Jones (capt)
Replacements: 16 Huw Bennett 17 Duncan Jones 18 Jonathan Thomas 19 Tom Smith 20 Jamie Nutbrown 21 Dan Biggar 22 Tommy Bowe
Porthcawl recently received a WRU facilities grant and funding from Natwest RugbyForce in order to give their changing rooms a facelift. This came after receiving £10,000 in a WRU facilities grant last year to tarmac their car park. The improvements have already helped to make the club more accessible, not only for their own members and players but for the whole community.
The Welsh Rugby Union has launched a new, accredited Safeguarding and Protecting Children course - funded by the WRU and delivered in partnership with Sport Wales and the NSPCC - fo rugby club volunteers around Wales.
The SWALEC semi-final draws threw up some mouth-watering clashes in the Cup, Plate and Bowl as the 12 teams aim for the Millennium Stadium Finals Day. All the semi-finals are to be played on the weekend of April 12.
Welsh whistler Rhys Thomas continues to scale the heights of the game as he prepares to be an official in this weekend's Hong Kong Sevens tournament, undoubtedly the showpiece event on the World Series calendar.
Wales International Ian Evans and Wales and Lions legend Scott Quinnell swapped rugby balls for paint pots at Tonna during the RBS 6 Nations. They surprised club players with a special clubhouse makeover to launch NatWest RugbyForce 2014 - a programme developed in partnership with the WRU to make rugby clubs stronger businesses by improving and renovating their facilities with the support of volunteers and the local community.
Fresh from claiming the Bowl honours in Tokyo last Sunday, the Wales Sevens squad have settled into their routine as they prepare for this weekend's Hong Kong tournament where Iolo Evans is aiming high, as WRU TV's Graeme Gillespie discovers.
The Welsh Rugby Union has recently teamed up with Prostate Cymru to help the charity launch its latest campaign to raise awareness of the disease. Members of the Wales squad helped produce a short video and promotional material for the campaign titled 'The Best Defence - is to know the FACTS'.