Jonathan Thomas returns to action after seven months out through a groin injury, and is joined among the replacements by British & Irish Lion Tommy Bowe, who will make his first appearance of the season if he comes on from the bench.
Sonny Parker comes into the squad to replace Jonathan Spratt, who has shown signs of fatigue in training this week and has been rested. He is expected to train as normal over the coming week and will be available for selection next weekend.
Ospreys coach Jonathan Humphreys commented: "We welcome back Jonathan Thomas after a lengthy lay-off and it's great to see him back again, he's had a pretty frustrating time of it but he's on the comeback trail which is great news. Likewise, with Tommy returning to action after the Lions tour, it's good to see the options available to us as coaches increasing.
"We're pretty satisfied with the result in Connacht last week, to come away from what is a difficult place with a win. It could have been far worse, there were some surprising results in the first week. It was our intention to get off to a positive start and we did that. There's still a lot for us to work on, which is quite pleasing really, we don't want to be hitting the ground at 100 per cent, we are building into it and as the season progresses we'll pick up the percentages as we go.
"We've looked at the video of last weekend's game, we've worked hard to improve in certain areas, and I'd expect to see us stepping up a level on Saturday evening. We want to go out on Saturday and send the right messages out to our supporters, in terms of what we want to achieve this season. We're very excited about coming back for the start of the season and it'll be great to see a big crowd waiting for us.
"As long as our mentality is right, as long as we show the pride I expect in the performance for the first home game and set the standards, we'll be alright and it will set us off in good stead for the rest of the season. The rest will follow."
Ospreys: 15 Barry Davies 14 Jonny Vaughton 13 Sonny Parker 12 Andrew Bishop 11 Nikki Walker 10 James Hook 9 Mike Phillips; 1 Paul James 2 Richard Hibbard 3 Cai Griffiths 4 Ian Gough 5 Andy Lloyd 6 Jerry Collins 7 Marty Holah 8 Ryan Jones (capt)
Replacements: 16 Huw Bennett 17 Duncan Jones 18 Jonathan Thomas 19 Tom Smith 20 Jamie Nutbrown 21 Dan Biggar 22 Tommy Bowe
Wales head coach Rob Howley explains his decision to change the captaincy of the national side with Ospreys second row Alun Wyn Jones taking over from Sam Warburton for the forthcoming RBS 6 Nations. Howley is hoping his decision will allow Warburton to rediscover his 'mojo'.
How do you follow a dancing hippopotamus - the Ospreys wheelchair rugby team has just the 'oneness' to do it say the BBC! For a decade the sight of a herd of hippos synchronised swimming around their own private blue lagoon, has lit up our television screens at regular intervals between favourite BBC One shows. But now the nation's most watched channel has relinquished its famous amphibious mammals in favour of a new show-reel which includes the Ospreys wheelchair rugby team.
Head coach Rowland Phillips and key front rower Carys Phillips look ahead to games against Spain and Ireland as Wales Women ramp up their preparations for the forthcoming Six Nations. The two warm-up games are a 'massive opportunity to refine the squad' according to the Welsh camp.
Martyn Phillips has discussed details of the newly published 'Strategy for Welsh Rugby' which puts in black and white terms the plans and direction of the governing body of the national sport in Wales for the next decade.
WRU chief executive Martyn Phillips has urged Welsh rugby fans to follow in the footsteps of their soccer counterparts at last summer's Euro Championship by backing their team to the hilt in the upcoming RBS 6 Nations campaign.
Chief executive Martyn Phillips has highlighted the plans for Wales to become a breeding ground for national and elite club rugby coaches, which are contained in the WRU's 10-year 'Strategy for Welsh Rugby'.
Andrew Coombs is enjoying his new role as Nelson forwards coach. The former Dragons and Wales lock has big ambitions to become a professional coach but feels it's important to learn the ropes in grassroots rugby and where better than his home club Nelson, with friends and family close to hand.
Students at Brynllywarch Hall School, near Newtown, have transformed their own lives, and are now having a positive impact on others through rugby. The sport has had a life-changing effect on the well-being of the students who are now delivering rugby sessions to local primary schools and playing for a new mixed ability side
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.