Wales flanker Gavin Thomas and former All Black Simon Maling will be released by the Scarlets this summer.
Thomas, 31, has been sidelined since November when he snapped his Achilles tendon. And Maling, 33, has suffered a string of injuries since moving to Wales from Japanese rugby last year.
Those problems have lead the Scarlets to cut their contracts for next season. Scarlets Chief Executive Stuart Gallacher said: "We have taken the difficult decision to part company with both of these players at the end of the season," said Gallacher.
"The 26-week injury clause is standard within professional rugby contracts and is something that all players are aware of when they join us."
Thomas won the last of his 22 Wales caps in 2007 having joined the Scarlets in 2004 while lock Maling, who played 11 times for the All Blacks between 2001 and 2004, has spent less than a year at Llanelli since moving from Japan.
Gallacher said: "We will be in ongoing dialogue with them and will support them where possible in any future moves. We are grateful to Simon and Gavin for what they have done for the Scarlets."
Scarlets coach Nigel Davies said a similar issue regarding Dafydd James' contract is "ongoing", though the region is said to be close to announcing more "significant" signings.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.