Mike Phillips resumes his regional partnership with Ospreys fly-half James Hook.
Mike Phillips will start for Wales against Italy in their RBS 6 Nations clash at Stadio Flaminio on Saturday - replacing the injured Dwayne Peel.
A hamstring tear means Sale Sharks scrum-half Peel will be out of action for at least a month.
Phillips is promoted from the replacements bench to the starting line-up and resumes his regional partnership with Ospreys fly-half James Hook, whilst London Irish scrum-half Warren Fury is handed the chance to win his third Wales cap as a replacement.
Scarlets scrum-half Martin Roberts has been ruled out of the trip to face the Azzuri with a rib cartilage problem, but his fitness will be judged again next week with a view to being in contention to face Ireland at the Millennium Stadium the following weekend.
"Martin has not been able to take a full part in training this week, but will be re-assessed early next week," said Wales physio Mark Davies.
"Dwayne will be out for a minimum of four weeks after a scan revealed a tear to his hamstring and we all wish him a speedy recovery."
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s