Mike Phillips resumes his regional partnership with Ospreys fly-half James Hook.
Mike Phillips will start for Wales against Italy in their RBS 6 Nations clash at Stadio Flaminio on Saturday - replacing the injured Dwayne Peel.
A hamstring tear means Sale Sharks scrum-half Peel will be out of action for at least a month.
Phillips is promoted from the replacements bench to the starting line-up and resumes his regional partnership with Ospreys fly-half James Hook, whilst London Irish scrum-half Warren Fury is handed the chance to win his third Wales cap as a replacement.
Scarlets scrum-half Martin Roberts has been ruled out of the trip to face the Azzuri with a rib cartilage problem, but his fitness will be judged again next week with a view to being in contention to face Ireland at the Millennium Stadium the following weekend.
"Martin has not been able to take a full part in training this week, but will be re-assessed early next week," said Wales physio Mark Davies.
"Dwayne will be out for a minimum of four weeks after a scan revealed a tear to his hamstring and we all wish him a speedy recovery."
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.