The game also sees top try scorer for the last two season's Jamie Jones return on the wing as Richard Hodges takes no chances against the Gwent side.
In the pack Ross Johnson, who was unavailable last week, returns at hooker and captain Nick Kelly returns in the second row although Wales Under 20's star Scott Andrews takes the captaincy for this Saturday.
In the back row, another Under 20's squad member, Josh Navidi starts at Number 8.
Glamorgan Wanderers: 15. James Loxton 14. Robin Lock 13. Simon Rosser 12. Dafydd Hewitt 11. Jamie Jones 10. Scott Sneddon 9. Glenn Holloway; 1. Mark O'Leary 2. Ross Johnson 3. Scott Andrews (capt)
4. Gareth Knight 5. Nick Kelly 6. Nio Aiono 7. Lee Highgate 8. Josh Navidi
Replacements: 16. Richard Emms 17. Nathan Trevett 18. Alex Luff 19. Alistair McDonald 20. Gareth Morris 21. Luke Evans 22. James Thomas