Gavin Henson is one of three players who make an Ospreys return.
Gavin Henson, Adam Jones and Tommy Bowe return to the Ospreys for the mouthwatering Heineken Cup clash against Perpignan at the Stade Aime-Giral.
Sonny Parker suffered a fractured rib against Munster last weekend and is likely to be out of action for 4/6 weeks which has forced Ospreys coach Sean Holley into a re-shuffle.
The in-form Andrew Bishop moves out a place to outside centre to accommodate Henson's return while a groin injury to Jonathan Thomas means Filo Tiatia starts to form a formidable backrow alongside fellow Kiwi Marty Holah and skipper Ryan Jones who plays on the blindside flank.
Holley said: "Saturday's game is a huge fixture that will provide a real test of physical and mental strength, but it's an exciting challenge that we are all looking forward to.
"You can't fail to be excited about the prospect of challenging one of France's leading sides on their own patch, in front of a big crowd and in an electric atmosphere. Our players are the type who thrive on competing against the best in the world in front of big, passionate crowds and Perpignan certainly fit the bill.
"Our recent matches against the Blues and Munster were both hugely physical, and as such, have proved to be excellent preparation for this fixture. We welcome back six seasoned internationals into the starting 15, along with Jamie Nutbrown on the bench, whilst Tom Smith deservedly takes a place in the 22 after a fine performance last weekend.
"After reviewing the Munster match we have identified clear areas for improvement, and if we can hit the right performance marks in terms of what we've been working hard on this week then we will present a serious challenge to Perpignan."
Ospreys: L. Byrne; T. Bowe, A. Bishop, G. Henson, S. Williams; J. Hook, M. Phillips; P. James, R. Hibbard, A. Jones, I. Gough, A.W. Jones, R. Jones (capt), F. Tiatia, M. Holah. Reps: H. Bennett, C. Griffiths, L. Bateman, T. Smith, D. Biggar, J. Vaughton
On the day the Wales U20 squad for the Six Nations is revealed, WRU Head of Rugby Performance Geraint John discusses the priorities of the Wales U20 programme, and moves being undertaken to make it easier for Welsh Exiles to be part of the WRU pathway - and to help keep Welsh qualified players in Wales
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Martyn Phillips has discussed details of the newly published 'Strategy for Welsh Rugby' which puts in black and white terms the plans and direction of the governing body of the national sport in Wales for the next decade.
WRU chief executive Martyn Phillips has urged Welsh rugby fans to follow in the footsteps of their soccer counterparts at last summer's Euro Championship by backing their team to the hilt in the upcoming RBS 6 Nations campaign.
Chief executive Martyn Phillips has highlighted the plans for Wales to become a breeding ground for national and elite club rugby coaches, which are contained in the WRU's 10-year 'Strategy for Welsh Rugby'.
Andrew Coombs is enjoying his new role as Nelson forwards coach. The former Dragons and Wales lock has big ambitions to become a professional coach but feels it's important to learn the ropes in grassroots rugby and where better than his home club Nelson, with friends and family close to hand.
Students at Brynllywarch Hall School, near Newtown, have transformed their own lives, and are now having a positive impact on others through rugby. The sport has had a life-changing effect on the well-being of the students who are now delivering rugby sessions to local primary schools and playing for a new mixed ability side
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.