With Richard Hodges away on Wales 7's duty Chris Ower takes charge and makes seven changes to the Wanderers line-up on their return to league action at Cross Keys.
Jason Pocock and Steve Cullen return in the back three and James Thomas gets a start at centre.
In the pack Rhys Gill and Nathan Trevett step into the front row with Ben Rose and Mike Grimes returning in the back-row. Nick Kelly regains the captaincy from Scott Andrews.
Glamorgan Wanderers: 15. Jason Pocock 14. Steve Cullen 13. Jamie Jones 12. James Thomas 11. Robin Lock 10. Scott Sneddon 9. Glenn Holloway; 1. Rhys Gill 2. Ross Johnson 3. Nathan Trevett 4. Gareth Knight 5. Nick Kelly (capt) 6. Nio Aiono 7. Ben Rose 8. Mike Grimes.
Replacements: 16. Ryan Price 17. Mark O'Leary 18. Tom Evans 19. Richard Thomas 20. Ben White 21. Luke Evans 22. Gareth Morris
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series