Llanelli make six changes, and two positional to the side which lost 19-16 to Aberavon last weekend for the clash against Bedford.
Hooker and influential captain Craig Hawkins again misses out due to injury and young Wales Under 20 hooker Rhys Lawrence gets the nod. He will be propped up by brothers Shaun and Aled Hopkins.
No 8 Rob McCusker will captain the team and along with energetic flankers Nic Cudd and Johnathan Edwards will form a formidable backrow.
Young Johnny Lewis in only his third game for the club makes his bow in the competition.
Llanelli 15 Jonny Lewis 14 Nick Reynolds 13 Steve Martin 12 Scott Williams 11 Andy Fenby 10 Dan Newton 9 Tavis Knoyle; 1 Shaun Hopkins 2 Rhys Lawrence 3 Aled Hopkins 4 Adam Powell 5 Aaron Shingler 6 Johnny Edwards 7 Nic Cudd 8 Rob McCusker (capt)
Replacements 16 Ian Jones 17 Luke Lewis 18 Jamie Corsi 19 Nathan White 20 Duane Eager 21 Gareth Davies 22 Steve Shingler
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series