Matthew Rees faces a spell on the sidelines after picking up a groin tear against the Wallabies.
Wales and Scarlets hooker Matthew Rees is likely to require surgery on the groin tear which saw him carried off on a stretcher against Australia at the Millennium Stadium in the final clash of the Invesco Perpetual Series of 2009.
Ospreys wing Shane Williams, who withdrew with a hamstring injury early in the first half, will not require surgery but will be in rehabilitation for a period of four to six weeks.
Squad captain Ryan Jones should be back in training this week after a back injury forced him to watch from the sidelines at the weekend and Leigh Halfpenny has joined the Baa-Baas squad still undergoing treatment for a dead leg.
"It is unclear at the moment as to the extent of Matthew's problem and we are currently in consultation with specialists but it is fair to say there is a strong likelihood that he will be requiring surgery and we will know more once that surgery has been undertaken," said Wales team physio Mark Davies.
"With Shane things are a little clearer, he has a grade two tear to his hamstring and will be out of action for four to six weeks undergoing treatment and rehab.
"Ryan will link back up with the Ospreys this week and should be taking some part in training and conditioning but will obviously be managed by his region. Leigh has reported for Baa-Baas duty and will receive treatment during the course of the week which should improve his situation."
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series