A new half-back pairing of Dwayne Peel and Nicky Robinson will start Wales' 600th international rugby match with Gareth Cooper and Daniel Biggar reverting to the bench.
Fit again Mark Jones replaces Chris Czekaj on the wing with McBryde keeping faith with the rest of the youthful backline which created so many chances against the Canucks.
With injury forcing Bradley Davies out of contention Ian Gough comes into the second row and Gareth Williams is preferred to Richard Hibbard at hooker with the back row remaining unchanged.
From the bench Sam Warburton could become Wales' 1,070th international and Luke Charteris, who flew into Chicago on Sunday night as a replacement for Davies, provides second row cover. Jonathan Spratt and Craig Mitchell also figure as replacements and could each win their second international caps.
"We have added some more experience to the back line with Mark Jones recovering from injury and both Nicky and Dwayne deserving their chances on this tour," said McBryde.
"It's a particularly tough call on Dan Biggar - it's not often you get a man-of-the-match performance and sit out the next one - but it is not a reflection on his performance, just a matter of giving Nicky the opportunity.
"Ian Gough also brings a wealth of experience to the pack with Gareth Williams handed a chance to show what he can do.
"We know we have another level in us and want to step up the intensity and improve on the performance from last week.
"We have an opportunity to finish the season on a high by producing the kind of rugby we know we are capable of against USA on Saturday and we are both determined to perform and focussed on the task ahead."
McBryde has resisted the temptation to make wholesale changes and give everyone a chance on tour, with Sonny Parker and Josh Turnbull the two players not to be used.
"Sonny has been a great tourist and he deserves credit for the contribution he has made to the tour behind the scenes, he answered a last minute call to replace James Hook after he was called up to Lions duty and he has shown his experience as an international rugby player by helping to take some of our younger squad members on," added McBryde.
"Josh is unlucky, but he will hopefully have benefited from the time he has spent in the international environment and will continue that learning experience for the rest of the week.
"There is an opportunity for him now to use the things he has learnt on this tour as a springboard for the future."
WALES: Daniel Evans; Mark Jones, Jonathan Davies, Andrew Bishop, Tom James; Nicky Robinson, Dwayne Peel; Duncan Jones, Gareth Williams, John Yapp, Ian Gough, Deiniol Jones, Dafydd Jones, Robin Sowden-Taylor, Ryan Jones
REPLACEMENTS: Richard Hibbard, Craig Mitchell, Luke Charteris, Sam Warburton, Gareth Cooper, Daniel Biggar, Jonathan Spratt.
WALES ALL-TIME RECORD: Played 599, Won 311, Drawn 27, Lost 261
WALES v USA
15 Daniel EVANS (SCARLETS - Cap No 1,067)
DoB: 15.11.88. 6'0" / 1.83m. 13st 9lbs / 87kgs
International record: 1 cap (W 1)
14 Mark JONES (SCARLETS - Cap No 984)
DoB: 07.11.79. 6'2" / 1.88m. 15st 0lbs / 95kgs
International record: 46 caps (W 21, L 23, D 2; 60 pts - 12T)
13 Jonathan DAVIES (SCARLETS - Cap No 1,066)
DoB: 05.04.88. 6'1" / 1.86m. 16st 3lbs / 103kgs
International record: 1 cap (W 1)
12 Andrew BISHOP (OSPREYS - Cap No 1,059)
DoB: 07.08.85. 6'0" / 1.83m. 15st 0lbs / 95kgs
International record: 5 caps (W 4, L 1)
11 Tom JAMES ( CARDIFF BLUES - Cap No 1,055)
DoB: 17.04.87. 6'2" / 1.88m. 15st 1lb / 96kgs
International record: 4 caps (W 1, L 3; 5 pts - 1T)
10 Nicky ROBINSON (CARDIFF BLUES - Cap No 1,016)
DoB: 03.01.82. 6'1". 14st 7lb
International record: 12 caps (W 6, L 6; 28 pts - 2T, 3PG, 3C, 1DG)
9 Dwayne PEEL (SALE SHARKS - Cap No 994)
DoB: 31.08.81. 5'9" / 1.76m. 13st 8lbs / 86kgs
International record: 68 caps (W 31, L 35, D 2; 25 pts - 5T)
1 Duncan JONES (OSPREYS - Cap No 997)
DoB: 18.09.78. 6'0" / 1.83m. 17st 8lbs / 112kgs
International record: 53 caps (W 24, L 27, D 2)
2 Gareth WILLIAMS (CARDIFF BLUES - Cap No 1,010)
DoB: 19.12.78. 5'8". 15st 4lbs
International record: 6 caps (W 1, L 5)
3 John YAPP (CARDIFF BLUES - Cap No 1,031)
DoB: 09.04.83. 6'2" / 1.88m. 18st 8lbs / 118kgs
International record: 13 caps (W 11, L 2)
4 Ian GOUGH (OSPREYS - Cap No 964)
DoB: 10.11.76. 6' 6" / 1.98m. 18st 9lbs / 118kgs
International record: 60 caps (W 28, L 29, D 3; 5 pts - 1T)
5 Deiniol JONES (CARDIFF BLUES - Cap No 981)
DoB: 18.11.77. 6'5" 1.96m. 17st 8lbs / 112kgs
International record: 6 caps (W 5, L 1)
6 Dafydd JONES (SCARLETS - Cap No 1,008)
DoB: 24.06.79. 6'3" / 1.90m. 17st 5lbs / 110kgs
International record: 40 caps (W 18, L 22; 10 pts - 2T)
7 Robin SOWDEN-TAYLOR (CARDIFF BLUES - Cap No 1,032)
DoB: 09.06.82. 6'1" / 1.86m. 15st 11lbs / 100kgs
International record: 7 caps (W 4, L 3)
8 Ryan JONES (OSPREYS, CAPTAIN - Cap No 1,029)
DoB: 13.03.81. 6'5" / 1.96m. 18st 0lbs / 114kgs
International record: 32 caps (W 18, L 13, D 1; 5 pts - 1T)
REPLACEMENTS
16 Richard HIBBARD (OSPREYS - Cap No 1,048)
DoB: 13.12.83. 6'0" / 1.83m. 17st 7lbs / 111kgs
International record: 8 caps (W 2, L 6)
17 Craig MITCHELL (OSPREYS - Cap No 1,068)
DoB: 03.05.86. 6'1" / 1.85m. 17st 2lbs / 109kgs
International record: 1 cap (W 1)
18 Luke CHARTERIS (NEWPORT GWENT DRAGONS - Cap No 1,030)
DoB: 09.03.83. 6'9" / 2.06m. 19st 9lbs / 125kgs
International record: 13 caps (W 7, L 6)
19 Sam WARBURTON (CARDIFF BLUES)
DoB: 05.10.88. 1.88m / 6'2". 15st 9lbs / 99kgs
International record: Uncapped
20 Gareth COOPER (GLOUCESTER RUGBY - Cap No 985)
DoB: 07.05.79. 5'7" / 1.71m. 13st 6lbs / 85kgs
International record: 41 caps (W 19, L 22; 40 pts - 8T)
21 Dan BIGGAR (OSPREYS - Cap No 1,063)
DoB: 16.10.89. 6'2" / 1.88m. 13st 9lbs / 87kgs
International record: 2 caps (W 2; 31 pts - 5C, 7PG)
22 Jonathan SPRATT (OSPREYS - Cap No 1,069)
DoB: 28.04.86. 6'2" / 1.88m. 16st 1lb / 102kgs
International record: 1 cap (W 1)
For further information please contact:
WRU National Squad Communications manager Simon Rimmer, srimmer@wru.co.uk. CANADA MOBILE: 001 4162629476, UK MOBILE: 0044 (0) 7825 981 128
