Springbok dangerman Schalk Burger has been ruled out of the first Test.
Schalk Burger has failed in his bid to be ready for the first Test between world champions South Africa and Ian McGeechan's British and Irish Lions touring side.
The fomer IRB world player of the year's niggling calf injury has failed to respond to treatment so Heinrich Brussow, who was a stand out performer in a losing Cheetahs side against the Lions earlier in the tour, is his replacement.
The Cheetahs flanker, who was called into the squad less than 24 hours ago as cover for the injured Burger, will start at blindside alongside his provincial team-mate Juan Smith.
South Africa will be led by John Smit, in a side stacked with experience. Sixteen players in the 22 were in South Africa's line-up for their previous Test against England at Twickenham in November last year.
Springbok play British and Irish Lions in first Test at Absa Stadium Saturday:
Francois Steyn; JP Pietersen, Adrian Jacobs, Jean de Villiers, Bryan Habana; Ruan Pienaar, Fourie du Preez; Pierre Spies, Juan Smith, Heinrich Brussow; Victor Matfield, Bakkies Botha; John Smit (capt), Bismarck du Plessis, Tendai Mtawarira
Replacements: Gurthro Steenkamp, Deon Carstens, Andries Bekker, Danie Rossouw, Ricky Januarie, Jaque Fourie, Morne Steyn
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.