The Cheetahs flanker, who was called into the squad less than 24 hours ago as cover for the injured Burger, will start at blindside alongside his provincial team-mate Juan Smith.
South Africa will be led by John Smit, in a side stacked with experience. Sixteen players in the 22 were in South Africa's line-up for their previous Test against England at Twickenham in November last year.
Springbok play British and Irish Lions in first Test at Absa Stadium Saturday:
Francois Steyn; JP Pietersen, Adrian Jacobs, Jean de Villiers, Bryan Habana; Ruan Pienaar, Fourie du Preez; Pierre Spies, Juan Smith, Heinrich Brussow; Victor Matfield, Bakkies Botha; John Smit (capt), Bismarck du Plessis, Tendai Mtawarira
Replacements: Gurthro Steenkamp, Deon Carstens, Andries Bekker, Danie Rossouw, Ricky Januarie, Jaque Fourie, Morne Steyn