Ospreys and Wales prop Adam Jones and Ireland centre Brian O'Drisoll, who both suffered injuries against South Africa in Saturday's titanic second Test in Pretoria, will return to Britain tomorrow.
O'Driscoll and Jones were among several Lions players who had to leave the field with injuries in a match where the world champions claimed the series with one Test still to play.
Jones dislocated his right shoulder during the match and received hospital treatment in order to have the shoulder put back into place. He will return home for further specialist opinion and treatment.
Jones said, "It is always disappointing to be ruled out of a Test series through injury but I am proud of what the squad and I have achieved on the tour. Personally I will always remember playing in the two first Tests and especially running on for my debut in the starting XV at Loftus Versfeld. My heart will be with the boys on Saturday."
O'Driscoll suffered a concussion in the match and began the return to play on Monday. However it soon became clear at the start of the process that he was not going to be ready for a return to action for Saturday's third Test in Johannesburg.
O'Driscoll said, "Being a part of the 2009 British & Irish Lions squad has been one of the highlights of my career. We were unbeaten leading into the Test matches and it is a shame that the results in the Tests did not go our way but sport comes down to fine margins at times. We could easily have won the first two Tests but it wasn't to be.
"I have decided to return home to my family this week after a very long season and to ensure I give myself every opportunity to recouperate."
Gethin Jenkins who suffered a broken cheekbone in the same match and was also ruled out of the rest of the tour will stay with the tour party. He has a review appointment with the surgeon on Friday. With just one match remaining on the tour the British & Irish Lions will not call for replacement players.
James Robson provided further medical update "The two other players who suffered injury in the second test, Tommy Bowe and Jamie Roberts, continue to be assessed on a daily basis but at this point they are making encouraging progress."
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.