Chris Czekaj, Richard Mustoe, Casey Laulala, Tom James, Ceri Sweeney and Tom Slater all return to the backline with Dafydd Hewitt keeping his place at inside centre.
In the forwards the Blues welcome back Andries Pretorius, Paul Tito, Fau Filise and Gareth Williams.
Cardiff Blues take on an unbeaten Harlequins side this Sunday, 6 February, 3.15pm kick off, at The Stoop. With the Quins the only side in the competition to have a 100% record following their convincing 38-13 win over London Wasps in Abu Dhabi. However, the Blues have beaten the Quins in their last five encounters
The Blues will need to win and hope that Newcastle Falcons slip up against Exeter and for London Wasps to lose to the Ospreys if they are to progress to the semi final stages of the competition.
Blues 15 Chris Czekaj 14 Richard Mustoe 13 Casey Laulala 12 Dafydd Hewitt 11 Tom James 10 Ceri Sweeney 9 Tom Slater; 8 Tom Brown 7 Josh Navidi 6 Andries Pretorius 5 Paul Tito (c) 4 Bryn Griffiths 3 Taufa'ao Filise 2 Gareth Williams 1 Tom Davies
Replacements: 16 T Rhys Thomas 17 Sam Hobbs 18 Nathan Trevett 19 Maama Molitika 20 Ben White 21 Rhys Downes 22 Gavin Evans 23 Dan Fish