Ieuan Davies, Owen Sheppeard and Joseff Griffin come in on the bench, while Aled Davies (knee operation), Lewis Smout (knee ligament), Rheon James (tonisilitis) were also unavailable.
Edwards said: "We are happy with the all-round performance of the team on Saturday but we want to make the squad as competitive as possible and the only way of doing that is to expose players to international rugby. By the time we get to our next home game, against Ireland at Parc y Scarlets on March 11, all our players will have gained a good amount of game time and we should know our best side.
"What was pleasing about the performance against England was our physicality which didn't drop off right up until the final whistle. That was particularly encouraging because England always present a physical challenge.
"We said that the England game would give us a benchmark, and the second half of the game did that, but our challenge now against Scotland is to come out and play like that from the start. If we play like that, I'm sure our results will look after themselves."
There is free entry to Bridgehaugh Park, Stirling for Friday's game.
Wales U20 team v Scotland (Friday 11 February, 7.30pm, Stirling)
Liam Williams (Llanelli); Adam Warren (Llandovery), Ben John (Ospreys / Aberavon), Owen Williams (Blues / Cardiff), Eli Walker (Ospreys / Swansea); Steven Shingler (Scarlets / Llanelli), Jonathan Evans (Dragons); Rhodri Jones (Scarlets / Llanelli), Sam Parry (Llandovery), Will Griff John (Blues / Pontypridd), Macauley Cook (capt, Blues / Cardiff), Cory Hill (Blues / Pontypridd), Ed Siggery (Pontypridd), Luke Hamilton (Blues / Glamorgan Wanderers), Ben Thomas (Ospreys /Bridgend).
Replacements: Ieuan Davies (Cardiff), Will Taylor (Ospreys / Swansea), Matthew Screech (Blues / Pontypridd), Owen Sheppeard (Blues / Pontypridd), Lewis Jones (Pontypridd), Joseff Griffin (Blues / Cardiff), Jack Gadd (Bristol)