Four East's Senghenydd are anxious to make it all the way this season and they set their stall out with a resounding 43-0 home victory over Blaenavon. They have been given another home tie with Monmouth of Five East who defeated COBRA 19-5 travelling to Welfare Park.
Amman United have been drawn at home to Porth of Four South East. The Four West outfit beat Tenby 31-18 while Porth were outscoring Rhiwbina 46-24 to reach the quarters.
The final tie will see Tonyrefail of Four South East play host to Maesteg Quins of Four South West in what could be an even contest. A try from wing Huw Morris helped Tonyrefail to a 14-7 win over last season's beaten finalists Trebanos, while Quins beat visitors Llanybydder 39-18.
SWALEC Bowl quarter-final draw
(ties to take place weekend of 26 March)
Amman United v Porth Quins
Cardiff Medicals v Vardre
Senghenydd v Monmouth
Tonyrefail v Maesteg Quins.