Both teams enter this afternoon's clash with two wins apiece in the championship.
Wales are hoping to make this afternoon an uncomfortable day at the office for Ireland as the men in green attempt to keep their RBS 6 Nations title ambitions on track (KO 5pm).
Irish players have tasted a lot of success in Cardiff and don't arrive with the baggage of a lot of other sides who fear the Millennium Stadium factor.
Ireland clinched the Grand Slam in 2009 at the Millennium Stadium while the Munster players within the Irish squad have tasted double success in the Heineken Cup with victories in 2006 and 2008.
Wales forwards coach Robin McBryde is fully aware Matthew Rees and co have it all to do if they are to keep their own title ambitions alive. But with both teams having a similar record with two wins from three games, something will have to give this afternoon.
McBryde said: "I think it's fair to say both teams are struggling to find their top form, to really play at the best of their ability and have that accuracy under the pressure that international rugby brings.
"Hopefully, both teams will bring their best game to the table. We know how comfortable Ireland are coming to Cardiff, so hopefully we can make it as uncomfortable as possible. It will be about the small margins."
Meaanwhile Ireland fly-half Ronan O'Gara needs just two points to reach 1,000 at international level which would put him alongside just four other players - Neil Jenkins, Jonny Wilkinson, Dan Carter and Diego Dominguez.
Jenkins said: "What can you say about Ronan? He has done everything. He is a Munster legend, and now he needs just a couple of points for a 1,000.
"If I see him I am sure I will have a bit of banter with him, as he is getting close to my number (of points). He is a legend of the game and a legend of Irish rugby."
Wales: L Byrne (Ospreys); L Halfpenny (Cardiff Blues), J Roberts (Cardiff Blues), J Davies (Scarlets), S Williams (Ospreys); J Hook (Ospreys), M Phillips (Ospreys); P James (Ospreys), M Rees (Scarlets, capt), C Mitchell (Ospreys), B Davies (Cardiff Blues), A-W Jones (Ospreys), D Lydiate (Newport Gwent Dragons), S Warburton (Cardiff Blues), R Jones (Ospreys).
Replacements: R Hibbard (Ospreys), J Yapp (Cardiff Blues), J Thomas (Ospreys), R McCusker (Scarlets), D Peel (Sale Sharks), S Jones (Scarlets), M Stoddart (Scarlets).
Ireland: L Fitzgerald (Leinster); T Bowe (Ospreys), B O'Driscoll (Leinster, capt), G D'Arcy (Leinster), K Earls (Munster); R O'Gara (Munster), E Reddan (Leinster); C Healy (Leinster), R Best (Ulster), M Ross (Leinster), D O'Callaghan (Munster), P O'Connell (Munster), S O'Brien (Leinster), D Wallace (Munster), J Heaslip (Leinster).
Replacements: S Cronin (Connacht), T Court (Ulster), L Cullen (Leinster), D Leamy (Munster), P Stringer (Munster), J Sexton (Leinster), P Wallace (Ulster).
Whenever Bedlinog tackle Penallta a massive fixure is guaranteed but this Sunday there will be even more emphasis placed on the two rivals when they contest the SSE Swalec Plate final at Principality Stadium.
Ahead of their SSE SWALEC Bowl Final clash with Taffs Well at Principality Stadium on Sunday, Burry Port share their #FABXV nomination with WRUTV in the search for Welsh rugby's greatest volunteers. Everyone can get involved by sending nominations via twitter to @WRU_Community using the hashtag #FABXV
Cardiff Blues prop Gethin Jenkins and Ospreys centre Ben John look ahead to the first game at Principality Stadium in Saturday's double header which is promising to be a special occasion for all Welsh fans.
Carmarthen Quins Director of Rugby Ian Jones and committee member Jeff Thomas along with Llandovery chairman Handel Davies look ahead to Sunday's SSE SWALEC Cup showdown where both teams are out to prove 'West is best'
SWALEC ambassador Shane WIlliams is looking forward to Sunday's Finals Day where the Cup, Bowl and Plate offers a great opportunity for players and teams to experience the magic of playing at Principality Stadium
Carmarthen Quins coach Richard Kelly believes it is an exciting time to be part of the Scarlets region as his side take on local rivals Llandovery in the SSE Swalec Cup final on Sunday, as WRU TV's Graeme Gillespie discovers
Scarlets long serving prop Phil John talks to WRU TV's Graeme Gillespie about Judgement Day IV and SSE Swalec Cup finals day. The last time Llandovery were in the cup final in 2007, the Drovers claimed the spoils with Phil playing a major role in the engine room.
Meet Aberdare coach Luke Thomas whose #FABXV nomination goes to super volunteer Daz with a whopping 10 things he does for the club each week, all except the ironing! You can also join in the search for Welsh rugby's greatest volunteers, by sending your nomination via twitter to @WRU_Community using the hashtag #FABXV
SSE Swalec Cup kings Pontypridd travelled to Swansea, fully expecting a return to their second home but Llandovery had other ideas as they also sought victory in the semi-final to earn the right to play the final at Principality Stadium