Wales fly-half Stephen Jones returns to the team, while Scott Williams, Aaron Shingler and Ben Morgan are also included after the defeat to Munster.
"We were disappointed with the final result last week against Munster, in many areas of the game we out-played and performed them but lacked that edge and winning mentality - which Munster have," said Scarlets head coach Nigel Davies.
"It was a performance reflective of our season, with a lot of promise but we're just not able to finish off tight encounters. We've created lots of scoring opportunities and played all the rugby - but we have to be more accurate and balance our performance with the right mentality to win.
"The structure's good, and defensively since Europe we've been one of the top three performers in the league. There's a lot of good stuff happening but we're just not nailing those wins - it's a big frustration to us and we have to put it right.
"We've been very hard on ourselves this week - we have to get results in our next two games and that is all that we can focus on. Europe is important to us and to maintain control of that we have to win our final games. We know that there's pressure on but we have to deal with that and I'm expecting this team to go out there and perform.
"It's a difficult place to play and Glasgow will play to their strengths and their home field. We've trained on a reduced size pitch this week and the side that wins the kicking battle and exerts the most pressure in that area will undoubtedly come out on top."
Scarlets: Morgan Stoddart, George North, Gareth Maule, Scott Williams, Sean Lamont, Stephen Jones, Tavis Knoyle, Iestyn Thomas, Matthew Rees (capt), Rhys Thomas, Lou Reed, Aaron Shingler, Rob McCusker, Johnathan Edwards, Ben Morgan.
Replacements: Emyr Phillips, Phil John, Simon Gardiner, Dominic Day, David Lyons, Martin Roberts, Rhys Priestland, Daniel Evans.