Ten of the squad are already capped from last season's matches with Matthew Jones reclaiming the No 10 jersey in a side captained by No 8 Jonathan Mills. Wing Aled Brew follows in the footsteps of brother Nathan - who went on to win a senior cap - while there are two new faces on the replacements bench in Cardiff prop Phillip Osborne and Penzance scrum half Rhodri McAtee.
Wales finished sixth in last summer's World Cup, losing twice to England in Glasgow, 23-14 and 26-19, as well as going down 22-19 in a Six Nations thriller at Gloucester last season.
Wales under 21: Ricky Williams (Newport); Aled Brew (Ospreys/Neath), Andrew Bishop (Neath), Gavin Evans (Scarlets/Llanelli), Chris Czekaj (Cardiff); Matthew Jones (Ospreys), Wayne Evans (Carmarthen Quins); Scott Roberts (Bridgend), Duane Goodfield (Pontypridd), Cai Griffiths (Neath/Ospreys), Alun Wyn-Jones (Swansea), Ian Evans (Neath), Chris Davies (Bridgend), Rhys Shellard (Pontypridd), Jonathan Mills (Scarlets, captain)
Replacements: Rhys James (UWIC), Ross Davies (Newbridge), Phillip Osborne (Cardiff), James Merriman (Hartpury Coll/Gloucester), Tom Smith (Neath), Aled Thomas (Carmarthen Quins), Rhodri McAtee (Penzance)
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series