Newport slumped to another defeat and can now kiss goodbye any prospect of reaching the quarter-finals of the Celtic League.
A week that started with Alix Popham invoking a clause in his contract to move on to Leeds, saw Jon Pritchard and Ceri Jones ruled out for two months with fractures and then Andy Powell pull out of the trip to Galway with a shoulder injury, simply got worse at the Showgrounds.
Building on the momentum they have gathered in winning away at Scottish Borders and Leinster Lions, as well as pipping Cardiff at home by a point, Connacht virtually guaranteed themselves another trip to the knock-out phase with a victory by two tries to nil.
The only points Newport could muster came from the boot of Shane Howarth, back in the outside half position because of a groin injury suffered by Jason Strange, who kicked two penalties in each half.
In doing so, the former Wales full back hoisted himself to the top of Newport's all-time points scoring list as he moved to 997. That took him past Paul Turner's record of 992.
Often criticised for his goal kicking, Howarth hit the post with one other attempt but was sound throughout on his return to the No 10 jersey.
"Once again it was a game we could and maybe should have won. We created a lot of chances, but we couldn't finish them off," said Newport team manager Jim McCreedy.
"We had a lot of territory, but we are falling down in the last five metres of the pitch. Ofisa Tonu'u was held up twice just short of the line.
"It's sad - we seem to have lost the habit of winning games and can't seem to break our losing run."
A mix up behind the scrum helped to pave the way for Ireland Under 21 cap James Norton to mark his debut with a try from full back for the home side.
Norton showed his elusive running skills to make the break with a side step and then great pace to race 40 metres to the line, .Eric Elwood couldn't add the conversion, but he did slot a penalty to give Connacht an 8-6 interval lead.
After the break, Howarth added two more penalties, but the game breaker came when left wing Wayne Munn grabbed a second try for the home side. This time Elwood added the conversion and the former Irish outside half also kicked a second penalty to maintain his side's 100 per cent record.
Scorers: Connacht: Tries: J Norton, W Munn; Con: E Elwood; Pens: E Elwood
2. Newport: Pens: S Howarth 4.
NEWPORT: M Pini; M Mostyn, A Marinos, S Williams, A Cadwallader; S Howarth,
O Tonu'u; R Snow, P Young (J Richards 55), C Anthony (A Garvey 55), M Veater (M Voyle 41), S Raiwalui (captain), A Popham, G Gravell, J Forster.
CONNACHT: J Norton; T Robinson, D Yapp, T Allnutt (captain), W Munn; E
Elwood, C Keane (O Reddan 55); D McFarland (R McCormack 52), J Flannery (M Uijs 52), P Bracken, W Waugh (E Peters 73), R Frost, M Swift, C Rigney (J O'Connor 50), J O'Sullivan.
Referee: R Maybank (RFU)
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.