Newport slumped to another defeat and can now kiss goodbye any prospect of reaching the quarter-finals of the Celtic League.
A week that started with Alix Popham invoking a clause in his contract to move on to Leeds, saw Jon Pritchard and Ceri Jones ruled out for two months with fractures and then Andy Powell pull out of the trip to Galway with a shoulder injury, simply got worse at the Showgrounds.
Building on the momentum they have gathered in winning away at Scottish Borders and Leinster Lions, as well as pipping Cardiff at home by a point, Connacht virtually guaranteed themselves another trip to the knock-out phase with a victory by two tries to nil.
The only points Newport could muster came from the boot of Shane Howarth, back in the outside half position because of a groin injury suffered by Jason Strange, who kicked two penalties in each half.
In doing so, the former Wales full back hoisted himself to the top of Newport's all-time points scoring list as he moved to 997. That took him past Paul Turner's record of 992.
Often criticised for his goal kicking, Howarth hit the post with one other attempt but was sound throughout on his return to the No 10 jersey.
"Once again it was a game we could and maybe should have won. We created a lot of chances, but we couldn't finish them off," said Newport team manager Jim McCreedy.
"We had a lot of territory, but we are falling down in the last five metres of the pitch. Ofisa Tonu'u was held up twice just short of the line.
"It's sad - we seem to have lost the habit of winning games and can't seem to break our losing run."
A mix up behind the scrum helped to pave the way for Ireland Under 21 cap James Norton to mark his debut with a try from full back for the home side.
Norton showed his elusive running skills to make the break with a side step and then great pace to race 40 metres to the line, .Eric Elwood couldn't add the conversion, but he did slot a penalty to give Connacht an 8-6 interval lead.
After the break, Howarth added two more penalties, but the game breaker came when left wing Wayne Munn grabbed a second try for the home side. This time Elwood added the conversion and the former Irish outside half also kicked a second penalty to maintain his side's 100 per cent record.
Scorers: Connacht: Tries: J Norton, W Munn; Con: E Elwood; Pens: E Elwood
2. Newport: Pens: S Howarth 4.
NEWPORT: M Pini; M Mostyn, A Marinos, S Williams, A Cadwallader; S Howarth,
O Tonu'u; R Snow, P Young (J Richards 55), C Anthony (A Garvey 55), M Veater (M Voyle 41), S Raiwalui (captain), A Popham, G Gravell, J Forster.
CONNACHT: J Norton; T Robinson, D Yapp, T Allnutt (captain), W Munn; E
Elwood, C Keane (O Reddan 55); D McFarland (R McCormack 52), J Flannery (M Uijs 52), P Bracken, W Waugh (E Peters 73), R Frost, M Swift, C Rigney (J O'Connor 50), J O'Sullivan.
Referee: R Maybank (RFU)
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series