Table-topping Narberth are unbeaten so far this season. The Otters 34-24 midweek victory over Bonymaen kept them on top of the pile.
They will be looking to consolidate their position with maximum points on Saturday when they take on Whitland.
Joint leaders Pontypool are the only other unbeaten side in the division and were unstoppable on Wednesday night hammering Tondu 50-3. Pooler entertain 4th placed Llandovery in undoubtedly the most exciting fixture of the weekend.
Llandovery are just two points off top spot following their 23-12 midweek victory over Bedwas.
Cross Keys will be hoping to get back to winning ways after they lost their unbeaten record to Tredegar on Wednesday.
It won't be plain sailing as they host Aberavon who, even at this early stage in the season, look serious title contenders.
Tredegar travel to Llanharan looking to build on their midweek victory over Cross Keys. With both sides on six points, this will be a tense and tight battle.
Tondu will be out to put their midweek hiding behind them when they travel to Cardiff hoping to teach the Glamorgan Wanderers a lesson.
However, the home side will still be reeling from their thrashing against Aberavon and will see this game as the perfect match to get back on track.
Bonymaen play Beddau, with both sides looking for a result to kick start their season.
Two sides who are yet to get up and running this year are Rumney and Treorchy.
Rumney travel to Carmarthen while bottom placed Treorchy travel to Newbridge, where Jason Williams will expect to add to his record tally of 2,283 which he achieved in midweek.
The Wales Women's team headed to Dare Valley Country Park on a team bonding exercise as the entire squad got together for the very first time in preparation for this season's Six Nations championship which kicks off on Saturday with a clash against defending champions Ireland, in Donnybrook.
Wales Head Coach Warren Gatland discusses his team selection for the opening round of the RBS 6 Nations where he leads his side against Ireland, on Sunday. As WRU TV's Luke Brodley discovers, Gatland is fully aware of the challenges the defending champions pose
WRUTV caught up with Wales Women captain Rachel Taylor at the RBS 6 Nations launch and how a good crowd really helps boost the girls performance. Tickets for all three Women's home games at The Gnoll, Neath are available from www.wru.wales/tickets
The WRU Coach Core Apprenticeship scheme is developing young people who are already benefitting Welsh rugby while improving their own career prospects. WRU TV caught up with some of the individuals who are making a difference.