Table-topping Narberth are unbeaten so far this season. The Otters 34-24 midweek victory over Bonymaen kept them on top of the pile.
They will be looking to consolidate their position with maximum points on Saturday when they take on Whitland.
Joint leaders Pontypool are the only other unbeaten side in the division and were unstoppable on Wednesday night hammering Tondu 50-3. Pooler entertain 4th placed Llandovery in undoubtedly the most exciting fixture of the weekend.
Llandovery are just two points off top spot following their 23-12 midweek victory over Bedwas.
Cross Keys will be hoping to get back to winning ways after they lost their unbeaten record to Tredegar on Wednesday.
It won't be plain sailing as they host Aberavon who, even at this early stage in the season, look serious title contenders.
Tredegar travel to Llanharan looking to build on their midweek victory over Cross Keys. With both sides on six points, this will be a tense and tight battle.
Tondu will be out to put their midweek hiding behind them when they travel to Cardiff hoping to teach the Glamorgan Wanderers a lesson.
However, the home side will still be reeling from their thrashing against Aberavon and will see this game as the perfect match to get back on track.
Bonymaen play Beddau, with both sides looking for a result to kick start their season.
Two sides who are yet to get up and running this year are Rumney and Treorchy.
Rumney travel to Carmarthen while bottom placed Treorchy travel to Newbridge, where Jason Williams will expect to add to his record tally of 2,283 which he achieved in midweek.
Principality Stadium will host the UEFA Champions League Final in six weeks' time. WRU chairman Gareth Davies, Football Association of Wales chief executive Jonathan Ford and Ambassador Ian Rush joined young sports fans at the trophy arrival at the venue to celebrate the magnitude of the event on Saturday 3rd June (kick-off 19.45).
British and Irish Lions captain Sam Warburton is looking forward to bringing together players from Ireland, Scotland, England and Wales for the biggest challenge of their careers - a series against world champions, New Zealand.
For the fifth year running, Wales referee Nigel Owens will be in charge of proceedings at Judgement Day V at Principality Stadium. It promises to be 'extra special' for the Wales' favourite ref, as he will be making his 150th appearance in the league.
There will be no shortage of inside knowledge from Bowl Finalists Caerphilly and Amman United when they face each other on Sunday at National Finals Day. Caerphilly hooker Rhys Cleverly knows the Principality Stadium pitch better than most as a matchday groundsman, while Amman United can look to Wales' record try scorer Shane Williams for some helpful advice.
Two hundred and 40 teams competed in the inaugural Urdd WRU 7s held at Pencoed last week with Welsh internationals Steff Andrews and Jasmine Joyce impressed with the talent on display, as was Urdd chief executive, Sioned Hughes.
The countdown is on for Judgement Day V as tickets for the big day at Principality Stadium soar through the 50,000 mark. Players and coaches alike are bursting at the seams to play in the double header with Dragons coach Kingsley Jones claiming there is a 'real buzz' about the event.
WRU TV went behind the scenes when the four regions got together to test their skill set for the BBC's Scrum V Live rugby show, at the WRU National Centre of Excellene in the build up to Judgement Day V. Blues' Matthew Morgan was one of the stars of the show while the Dragons' Cory Hill proved a surprise package...the full set of results will be revealed on tv screens on matchday
Wales assistant coach Richie Pugh is confident his side can cause a few headaches in the Hong Kong Sevens this weekend. In a tough group, Wales kick off their campaign against New Zealand on Friday before playing Japan and Fiji, who are chasing their third consecutive Hong Kong title, on Saturday.
Bedwas had to overcome a stubborn Carmarthen Quins side before winning the Foster's Challenge Cup final in Bridgend with a 23-18 victory. Bedwas captain Nicky Griffiths pays tribute to his side who have claimed the club's first piece of silverware in the modern era.
Team coach Brett Davey is aiming to keep his unbeaten run in cup finals at Principality Stadium intact when his side take on Amman United in the WRU Bowl final, after he guided Caerphilly to a 20-14 win against Cilfynydd in the semi-finals.
Penallta are hoping to go one step further than last season when falling to Bedlinog in the WRU Plate Final. After a titanic struggle against Nant Conwy, they have given themselves a great chance, after a hard fought 18-13 semi-final victory.