Table-topping Narberth are unbeaten so far this season. The Otters 34-24 midweek victory over Bonymaen kept them on top of the pile.
They will be looking to consolidate their position with maximum points on Saturday when they take on Whitland.
Joint leaders Pontypool are the only other unbeaten side in the division and were unstoppable on Wednesday night hammering Tondu 50-3. Pooler entertain 4th placed Llandovery in undoubtedly the most exciting fixture of the weekend.
Llandovery are just two points off top spot following their 23-12 midweek victory over Bedwas.
Cross Keys will be hoping to get back to winning ways after they lost their unbeaten record to Tredegar on Wednesday.
It won't be plain sailing as they host Aberavon who, even at this early stage in the season, look serious title contenders.
Tredegar travel to Llanharan looking to build on their midweek victory over Cross Keys. With both sides on six points, this will be a tense and tight battle.
Tondu will be out to put their midweek hiding behind them when they travel to Cardiff hoping to teach the Glamorgan Wanderers a lesson.
However, the home side will still be reeling from their thrashing against Aberavon and will see this game as the perfect match to get back on track.
Bonymaen play Beddau, with both sides looking for a result to kick start their season.
Two sides who are yet to get up and running this year are Rumney and Treorchy.
Rumney travel to Carmarthen while bottom placed Treorchy travel to Newbridge, where Jason Williams will expect to add to his record tally of 2,283 which he achieved in midweek.
WRU International Skills Coach Jason Strange is a busy man, combining the new role with that of Wales Under 20 attack coach, Ebbw Vale head coach and continuing to teach at Ebbw Fawr Learning Community.
Warren Gatland and Sam Warburton look ahead to this week's crunch RBS 6 Nations tie against France, where the Wales skipper in particular is keen to make his mark, as Paris has proved a bleak place for him in the past.
Following their historic win over England, Wales Under 20 suffered a narrow, 36-34 loss to their Scottish counterparts last weekend, despite outscoring them by five tries to three. Watch the match highlights and reaction.
WRU TV go behind the scenes with the Wales squad as they put the final touches in place ahead of the clash against Scotland at Murrayfield. Follow the squad on their captain's run, the kickers visit to Murrayfield and Neil Jenkins' press conference