Leaders Narberth go on the road face Bonymaen, which means a quick return to Parc Mawr for Otters full back Adrian Killa, who played at scrum half for Bony last season.
Pontypool, in second place after defeating Aberavon on Saturday, will have a difficult match at Pandy Park, Tondu, where the home side are always difficult to beat.
Pontypool, like Naberth, have won all their four matches so far, but will be without skipper Mark Jones, who is out with a broken arm.
Cross Keys, also unbeaten after three wins and a draw, will have a tough task as they meet fellow Gwent club Tredegar, who are another tough club to beat at home.
Bedwas, after impressive wins at Carmarthen and Newbridge, will entertain Llandovery in what should be an entertaining match at Central Park, while Rumney will be hoping to record their first win of the season as they play host to Beddau for the first time in a league meeting.
Whitland meet Llanharan, who have already won twice under their new coach Dennis John, and Carmarthen Quins should overcome an improving Treorchy side.
Aberavon coach Chris O'Callaghan will be keen to see the Wizards back on the winning trail at home to Glamorgan Wanderers and Blackwood meet Newbridge in what is likely to be a keenly-contested local derby.
Divison 1 Fixtures. 24th Septemeber
Aberavon v Glamorgan Wanderers;
Bedwas v Llandovery;
Blackwood v Newbridge;
Bonymaen v Narberth;
Carmarthen Quins v Treorchy;
Rumney v Beddau;
Tondu v Pontypool;
Tredegar v Cross Keys;
Whitland v Llanharan.
Penallta are hoping to go one step further than last season when falling to Bedlinog in the WRU Plate Final. After a titanic struggle against Nant Conwy, they have given themselves a great chance, after a hard fought 18-13 semi-final victory.
The unique jeopardy of Judgement Day V has been described by stars from Cardiff Blues, Ospreys, Scarlets and Newport Gwent Dragons who will face each other in the annual double-header at Principality Stadium on 15th April.
School club hub officers in schools throughout Wales are enriching lives by helping pupils to engage more with their education, their community and improve their own outlook on life and future prospects by improving confidence and developing skills such as leadership.
WRU chief executive Martyn Phillips, WRU chairman Gareth Davies and Dragons chief executive Stuart Davies discuss the historic intentions of the governing body to assume operational control of the Newport Gwent Dragons, with a targeted completion date of 1st July.
Equal access to facilities and resources at St Helen's has seen Swansea Women flourish since being welcomed with open arms last July. Swansea RFC chairman Stephen Hughes and women's captain Siwan Lillicrap are delighted to see rapid progress being made on and off the pitch.
Young referee Ben Breakspear is making rapid strides as a referee. In just over a year he has gone from officiating a college game to being a touchline official during last weekend's RBS 6 Nations clash between Wales and Ireland at Principality Stadium.
Grand Slams, Triple Crowns and British and Irish Lions tours - Sir Gareth Edwards did it all. But what are his favourite moments in what was an amazing career? WRU TV finds out - along with his favourite players of today in the third and final instalment of our series with the greatest rugby player ever.
JPR Williams, Gerald Davies and Mervyn Davies were among those in the Welsh ranks when Sir Gareth Edwards began his international career against France nearly 50 years ago, but who was the player who took the young scrum half under their wing?
Wales head coach Rob Howley and captain Alun Wyn Jones are expecting a physical battle against France on Saturday but both are hoping for another impact from the bench as the men in red chase a top-four world ranking.
It's nearly 50 years since the great Sir Gareth Edwards made his debut as a youngster for Wales against France in Stade Colombes. In the first of a series, WRU TV discovers he pocketed a 'special momento' from the game - something he still has today.