Wales captain Scott Quinnell will face the Welsh All Blacks and then miss the next two Celtic League matches, at home to Ebbw Vale and away in Edinburgh, after opting for surgery on his troublesome nose.
The big No 8 has suffered from regular nose-bleeds since he took a knock on his hooter during the British Lions tour of Australia.
He will be out for two weeks, but the Scarlets have Dave Hodges back after his duties for the United States team.
Coach Gareth Jenkins said: "It is a great blow to the side to lose someone of the calibre of Scott, but we have a strong squad to choose from and it is best to get the problem sorted sooner rather than later."
WRU TV were on hand at the launch of a major new commercial deal with WRU and Mercedes-Benz South Wales (part of the Sinclair Group), which sees the family company become an official supplier to the Welsh Rugby Union
On the back of the recent Women's Rugby World Cup, the WRU has launched a revitalised Women's and Girls domestic seasonal structure, and the future is looking bright.
Go to www.wru.co.uk/tryourgame for more information
Roger Lewis talks to WRU TV at the announcement of a new £60 million Rugby Services Agreement (RSA) which provides a new and positive contractual relationship between the WRU and its four Regions for the next six years has been agreed.
The Welsh Rugby Union has announced a major new sponsorship deal with Gullivers Sports Travel which will make the UK's leading, and longest established, multi-sport tour operator, an Official Supplier for the rest of the decade.
Having taken part in seven World Cups as a player and coach, Liza Burgess hopes to go out in style this afternoon when Wales take on Australia in the Play-off for seventh and eighth place in the Women's Rugby World Cup in Paris.
WRU Head of Rugby Josh Lewsey met with volunteers across the game earlier this week, championing their role in the sport. He was joined by Wales captain Sam Warburton for part of the day as volunteers took part in a 'Try Out' event for the 2015 Rugby World Cup