Wales captain Scott Quinnell will face the Welsh All Blacks and then miss the next two Celtic League matches, at home to Ebbw Vale and away in Edinburgh, after opting for surgery on his troublesome nose.
The big No 8 has suffered from regular nose-bleeds since he took a knock on his hooter during the British Lions tour of Australia.
He will be out for two weeks, but the Scarlets have Dave Hodges back after his duties for the United States team.
Coach Gareth Jenkins said: "It is a great blow to the side to lose someone of the calibre of Scott, but we have a strong squad to choose from and it is best to get the problem sorted sooner rather than later."
Wales head coach Warren Gatland and captain Sam Warburton say their first prioirty on Sunday in the opening game of the World Cup is to win against Uruguay and not get overly concerned with points difference.
With only days to go until the biggest rugby competition in the world begins, rugby fans visiting Cardiff this autumn will be able to enjoy a special display at National Museum Cardiff as part of the celebrations surrounding the Rugby World Cup.
Geraint John has taken up the new role of WRU elite coach development manager having arrived in Wales last week. WRU TV caught up with him at the WRU rugby department's strategy day at the Millennium Stadium.
The entire Welsh Rugby Union Rugby Department gathered at the Millennium Stadium earlier this week where WRU Head of Rugby Josh Lewsey looked back on a year where structural and strategic changes have seen significant progress made
The Welsh Rugby Union has released a specially produced video to spearhead a new campaign to help promote the values of rugby union. The video, entitled Let us Play underpins the WRU rugby department's philosophy - to engage, transfer and retain players, coaches and referees.