Pieter Muller has recovered from knee surgery and plays his first game of the season against The Borders in Hawick on Friday evening (7.30 pm).
Also included in a Cardiff team that shows six changes from the side that started against Connacht is Dan Baugh. The Canadian back row star played 22 minutes as a replacement in Galway but will now make his first 'start' since playing for Canada in the summer.
Also brought into this week's team are international half-backs Iestyn Harris and Ryan Powell, wing Anthony Sullivan, loose-head prop Tim Payne and hooker Greg Woods.
Coach David Young said, "Our changes from match-to-match reflect our commitment to utilising the full squad wherever possible. I have been very happy with the midfield but Pieter Muller is fit and due for a game. Our half-backs played the full 80 minutes last week so now take their turn on the bench. Andrew Lewis has had a niggling injury this week but should be alright for the replacements' bench."
Unavailable for selection were Jim Brownrigg, Emyr Lewis, Spencer John, Dean Dewdney and Robin Sowden-Taylor.
Donavan van Vuuren trained with the squad this week and new lock Heino Senekal arrived at the Arms Park at lunchtime today.
Team: Rhys Williams; Anthony Sullivan, Jamie Robinson, Pieter Muller, Craig Morgan; Iestyn Harris, Ryan Powell; Tim Payne, Greg Woods, Kenneth Fourie, Adam Jones, John Tait, Rob Appleyard, Dan Baugh, Martyn Williams (captain)
Replacements: Gary Powell, Andrew Lewis, Luke Tait, Dan McShane, Richard Smith, Nick Robinson, Nick Walne
Referee: Dave Pearson (RFU)
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series